Four tablet samples (1.6308 g) which contain acetylsalicylic acid were dissolved in a 100 mL water/ethanol mixture. A 25-mL aliquot was obtained and titrated with standard 0.1273 N NaOH solution using a pH meter. The potentiometric data are given below. Calculate the % acetylsalicylic acid (EW=180.157 g/mol) per tablet. Prove that the active ingredient is indeed acetylsalicylic acid (pKa=3.48).

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Four tablet samples (1.6308 g) which contain acetylsalicylic acid were dissolved in a 100
mL water/ethanol mixture. A 25-mL aliquot was obtained and titrated with standard
0.1273 N NaOH solution using a pH meter. The potentiometric data are given below.
Calculate the % acetylsalicylic acid (EW=180.157 g/mol) per tablet. Prove that the active
ingredient is indeed acetylsalicylic acid (pKa=3.48).

POTENTIOMETRY POSTLAB QUESTION
Four tablet samples (1.6308 g) which contain acetylsalicylic acid were dissolved in a 100
mL water/ethanol mixture. A 25-mL aliquot was obtained and titrated with standard
0.1273 N NaOH solution using a pH meter. The potentiometric data are given below.
Calculate the % acetylsalicylic acid (EW=180.157 g/mol) per tablet. Prove that the active
ingredient is indeed acetylsalicylic acid (pKa=3.48).
18.00
12.00
16.00
14.00
10.00
12.00
pHa.00
10.00
8.00
6.00
6.00
4.00
4.00
2.00
2.00
0.00
5.00
10.00
15.00
20.00
25.00
0.00
13.0 13.2 13.4 13.6 13.8 14.0 14.2 14.4 14.6 14.8 15.0
Volume of titrant (mL)
Volume of titrant (mL)
Figure 1. Shows a plot of pH vs. mL of
titrant added
Figure 2. Shows a plot of ApH/AV vs. mL of
titrant added
ApH/AV
Transcribed Image Text:POTENTIOMETRY POSTLAB QUESTION Four tablet samples (1.6308 g) which contain acetylsalicylic acid were dissolved in a 100 mL water/ethanol mixture. A 25-mL aliquot was obtained and titrated with standard 0.1273 N NaOH solution using a pH meter. The potentiometric data are given below. Calculate the % acetylsalicylic acid (EW=180.157 g/mol) per tablet. Prove that the active ingredient is indeed acetylsalicylic acid (pKa=3.48). 18.00 12.00 16.00 14.00 10.00 12.00 pHa.00 10.00 8.00 6.00 6.00 4.00 4.00 2.00 2.00 0.00 5.00 10.00 15.00 20.00 25.00 0.00 13.0 13.2 13.4 13.6 13.8 14.0 14.2 14.4 14.6 14.8 15.0 Volume of titrant (mL) Volume of titrant (mL) Figure 1. Shows a plot of pH vs. mL of titrant added Figure 2. Shows a plot of ApH/AV vs. mL of titrant added ApH/AV
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