for the SN reaction 8 Br ON H. NacN DMF 3. H the ) assign the substrate Configuration of the chiral center in b) assign the configuation of the Chiral center in the product. C) Does this SN pocess proceed nith inversion Configuration? CExplain)

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### SN2 Reaction Analysis

**Reaction Description:**
A bromocyclopropane substrate undergoes an SN2 reaction with sodium cyanide (NaCN) in DMF (dimethylformamide). The bromine atom is replaced by a cyanide group, resulting in inversion of configuration at the chiral center.

**Diagram Explanation:**
- The substrate features a cyclopropane ring with a bromine (Br) atom attached.
- In the presence of NaCN and DMF, the nucleophile (cyanide ion) attacks the carbon atom bonded to the Br, causing the Br to leave.
- The reaction proceeds with a backside attack, resulting in an inversion of configuration.

### Questions

**a) Assign the configuration of the chiral center in the substrate:**

Identify the priority of the groups around the chiral center according to the CIP (Cahn-Ingold-Prelog) rules and determine its configuration (R or S).

**b) Assign the configuration of the chiral center in the product:**

After the reaction, reassess the priority of the substituents around the new chiral center and determine its configuration (R or S).

**c) Does this SN2 process proceed with inversion of configuration? (Explain):**

Explain how SN2 reactions typically lead to inversion due to the backside attack mechanism, resulting in the inversion of the stereochemistry at the chiral center.
Transcribed Image Text:### SN2 Reaction Analysis **Reaction Description:** A bromocyclopropane substrate undergoes an SN2 reaction with sodium cyanide (NaCN) in DMF (dimethylformamide). The bromine atom is replaced by a cyanide group, resulting in inversion of configuration at the chiral center. **Diagram Explanation:** - The substrate features a cyclopropane ring with a bromine (Br) atom attached. - In the presence of NaCN and DMF, the nucleophile (cyanide ion) attacks the carbon atom bonded to the Br, causing the Br to leave. - The reaction proceeds with a backside attack, resulting in an inversion of configuration. ### Questions **a) Assign the configuration of the chiral center in the substrate:** Identify the priority of the groups around the chiral center according to the CIP (Cahn-Ingold-Prelog) rules and determine its configuration (R or S). **b) Assign the configuration of the chiral center in the product:** After the reaction, reassess the priority of the substituents around the new chiral center and determine its configuration (R or S). **c) Does this SN2 process proceed with inversion of configuration? (Explain):** Explain how SN2 reactions typically lead to inversion due to the backside attack mechanism, resulting in the inversion of the stereochemistry at the chiral center.
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