Following is a synthesis for toremifene, a nonsteroidal estrogen antagonist whose struc- ture is closely related to that of tamoxifen. 1. THP-O -Br, Mg 1. E:ONA 2. BICH,CH,OBn 2. H,O, HCI BnO A B 0-THP 0-THP HO Ho+ ОН OH BnO НО C D Cl. NMeg HCI F Toremifene

Following is a synthesis for toremifene, a nonsteroidal estrogen antagonist whose struc- ture is closely related to that of tamoxifen. 1. THP-O -Br, Mg 1. E:ONA 2. BICH,CH,OBn 2. H,O, HCI BnO A B 0-THP 0-THP HO Ho+ ОН OH BnO НО C D Cl. NMeg HCI F Toremifene

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Q: Propose a mechanism for the conversion of F to toremifene

Question

Propose a mechanism for the conversion of D to E

Following is a synthesis for toremifene, a nonsteroidal estrogen antagonist whose struc-
ture is closely related to that of tamoxifen.
1. THP-O
-Br, Mg
1. E:ONA
2. BICH,CH,OBn
2. H,O, HCI
BnO
A
B

0-THP
0-THP
HO
Ho+
ОН
OH
BnO
НО
C
D
Cl.
NMeg
HCI
F
Toremifene

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