Following administration of an opiate drug, "pain signals" are prevented from getting out of the spinal cord via two mechanisms. One inhibits spinal cord neurons that communicate with the parafascicular nucleus of the thalamus. What is the other way that pain signals are stopped? dendro-dendritic synapses that enhance IPSI's in somatosensory neurons. the disinhibition of long axons that start in the spinal cord and influence free nerve endings directly. feedback loop to the periaquedictal grey of the midbrain, which enhances neural activity in that area. axo-axonic synapses that prevents somatosensory neurons from releasing neurotransmitter.

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Emotions

Emotions are biologically based psychological conditions caused by neurophysiological changes which are linked to different factors such as thoughts, emotions, behavioral responses, and pleasure or displeasure. These emotions are not similar to moods. The mood is an affective state. Mood depends upon several factors, such as weather, the environment, physiology, etc. Emotions can be beneficial or detrimental depending on the situation. Emotional reactions are simple. Emotional well-being is strongly affected by our well-being, and such feelings are private.