Figure 9.10 You isolate a cell strain in which the joining together of Okazaki fragments is impaired and suspect that a mutation has occurred in an enzyme found at the replication fork. Which enzyme is most likely to be mutated? -Origin of Replication RNA pimer Tempae srands Leading DNA Ssrand polymecse Seand Helicase DNA polymera Okazaki agment ONA agase RNA Figure 9.10 A replication fork is formed by the opening of the origin of replication, and helicase separates the DNA strands. An RNA primer is synthesized, and is elongated by the DNA polymerase. On the leading strand, DNA is synthesized continuously, whereas on the lagging strand, DNA is synthesized in short stretches. The DNA fragments are joined by DNA ligase (not shown).

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Figure 9.10 You isolate a cell strain in which the joining together of
Okazaki fragments is impaired and suspect that a mutation has occurred
in an enzyme found at the replication fork. Which enzyme is most likely
to be mutated?
-Origin of Replication-
RNA primer
Template
srands
Leading
DNA
Svand potymerse
Sand
Helicase
ONA
gme
DNA
RNA
Okazaki
magment
polymerase
Figure 9.10 A replication fork is formed by the opening of the origin of replication, and helicase separates the
DNA strands. An RNA primer is synthesized, and is elongated by the DNA polymerase. On the leading strand,
DNA is synthesized continuously, whereas on the lagging strand, DNA is synthesized in short stretches. The DNA
fragments are joined by DNA ligase (not shown).
Transcribed Image Text:Figure 9.10 You isolate a cell strain in which the joining together of Okazaki fragments is impaired and suspect that a mutation has occurred in an enzyme found at the replication fork. Which enzyme is most likely to be mutated? -Origin of Replication- RNA primer Template srands Leading DNA Svand potymerse Sand Helicase ONA gme DNA RNA Okazaki magment polymerase Figure 9.10 A replication fork is formed by the opening of the origin of replication, and helicase separates the DNA strands. An RNA primer is synthesized, and is elongated by the DNA polymerase. On the leading strand, DNA is synthesized continuously, whereas on the lagging strand, DNA is synthesized in short stretches. The DNA fragments are joined by DNA ligase (not shown).
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