Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter4: Basic Immunology And Immunohematology
Section4.2: Infectious Mononucleosis Tests
Problem 2RQ
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Question
Explain what pore-forming toxins are. Give an example of one and why this is medically
important.
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Toxins are a metabolic product of the organism that damages the host. It can induce disease in absence of the organism that produced them.
There are a few important points about pore-forming toxins :
- These toxins exert into the membrane of cells and form non-regulated forms.
- It allows water, ions, and small molecules to enter and exit into it and causes the death of the cell.
- Streptococcus pneumonia-producing pore-forming toxin.
The mode of action involved by pore-forming toxins are :
- Receptor recognition
- Activation by proteases
- Aggregation into the oligomeric structures
- Insertion into the membrane to form ionic forms.
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