Explain the SPECIFIC mechanism(s) by which moderate to advanced emphysema leads to right-sided heart failure - i.e. discussion the pathogenesis of emphysema which may alter ventilation/perfusion balance.  Additionally, do you think Albuterol, a commonly prescribed inhaled beta-agonist, would be of benefit in these patients?  Why or why not.   Lastly, explain what chemical is primarily responsible for stimulus to breathe and how this is altered in these patients.  Why might excessive oxygenation of these patients lead to excessive somnolence and even death?

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
ChapterCRE2: Comprehensive Review Exam For Part 2
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Problem 44CEP2
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Explain the SPECIFIC mechanism(s) by which moderate to advanced emphysema leads to right-sided heart failure - i.e. discussion the pathogenesis of emphysema which may alter ventilation/perfusion balance.  Additionally, do you think Albuterol, a commonly prescribed inhaled beta-agonist, would be of benefit in these patients?  Why or why not.  

Lastly, explain what chemical is primarily responsible for stimulus to breathe and how this is altered in these patients.  Why might excessive oxygenation of these patients lead to excessive somnolence and even death?

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