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- Explain the routes how SARS-COV-2 or can be transmitted from a diseased individual to a susceptible host.
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- Compare and contrast SARS COV-2 and. Influenza Type A Virus with respect to the following parameters: Type of genetic material. Receptor binding proteins of the envelope and receptor used by the virus to enter cells. Effects of virus on interferon induction and innate Inflammatory response.In addition to the tests described above, people can also get tested for the presence of SARS-CoV-2 antibodies. Explain how an individual could test negative for an active SARS-CoV-2 infection and positive for SARS-CoV-2 antibodies.Discuss the sequential steps of innate immune system activation in response to SARS-COV-2 infection with respect to the following parameters: Primary host tissue targets and receptors. Host PRRs. Parameters of interferon activation. Role of neutrophils, macrophages. ILCs and inflammasomes in the innate immune response. Soluble inflammatory factors and biomarkers linked to the "cytokine storm". Differences in the innate immune cell compartment in early versus late-stage disease in mild versus serious cases of COVID-19.
- List three virulence factors and explain their role in establishing a disease. What is the difference between multidrug resistance and cross-resistance? What is the difference between MIC and MBC?Discuss the sequential steps of innate immune system activation in response to SARS COV-2 infection with respect to the following parameters: Primary host tissue targets and receptors. Host PRRs. Parameters of interferon activation.Sequentially describe the five goals (attachment, entry, replication, assembly and release) of SARS-COV 2 during infection of a living cells.