Explain how the X and Y chromosomes are able to pair together in meiosis as homologous chromosomes. Also, explain what role the SRY region of the Y chromosome plays in determining maleness.

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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### Pairing of X and Y Chromosomes in Meiosis

**How the X and Y Chromosomes Pair Together as Homologous Chromosomes**

Despite their differences in size and genetic content, the X and Y chromosomes are able to pair together during meiosis due to regions of homology. These regions, known as pseudoautosomal regions (PARs), are present on both the X and Y chromosomes and allow them to align properly during the process of cell division. These pseudoautosomal regions contain the same genes on both chromosomes, which facilitates the correct pairing and segregation of these sex chromosomes during meiosis, ensuring the proper distribution of genetic material to the offspring.

### Role of the SRY Region in Determining Maleness

**The Function of the SRY Region on the Y Chromosome**

The SRY (Sex-determining Region Y) gene is crucial in determining maleness in mammals. Located on the Y chromosome, the SRY gene is responsible for initiating the development of male physical characteristics. More specifically, the SRY gene triggers a cascade of genetic events that lead to the formation of testes from the undifferentiated gonadal tissue during embryonic development. 

This process subsequently results in the production of male sex hormones (androgens), which drive the development of secondary male characteristics. Without the expression of the SRY gene, the default development pathway leads to female phenotype, even in the presence of a Y chromosome.
Transcribed Image Text:### Pairing of X and Y Chromosomes in Meiosis **How the X and Y Chromosomes Pair Together as Homologous Chromosomes** Despite their differences in size and genetic content, the X and Y chromosomes are able to pair together during meiosis due to regions of homology. These regions, known as pseudoautosomal regions (PARs), are present on both the X and Y chromosomes and allow them to align properly during the process of cell division. These pseudoautosomal regions contain the same genes on both chromosomes, which facilitates the correct pairing and segregation of these sex chromosomes during meiosis, ensuring the proper distribution of genetic material to the offspring. ### Role of the SRY Region in Determining Maleness **The Function of the SRY Region on the Y Chromosome** The SRY (Sex-determining Region Y) gene is crucial in determining maleness in mammals. Located on the Y chromosome, the SRY gene is responsible for initiating the development of male physical characteristics. More specifically, the SRY gene triggers a cascade of genetic events that lead to the formation of testes from the undifferentiated gonadal tissue during embryonic development. This process subsequently results in the production of male sex hormones (androgens), which drive the development of secondary male characteristics. Without the expression of the SRY gene, the default development pathway leads to female phenotype, even in the presence of a Y chromosome.
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