Explain how potassium is secreted in the DCT? T[K*] 3Na+ 3Na* 3Na* Aldo Kir4.1-5.1 2K+ 2K+ 2K+ ; Depolarization of membrane >1[CH] MR WNK→SPAK SGK1 NCC NCC NCC HENACE ROMKE GENAC ROMK Maxi-K (-charge) Increased >K+ flow Na+
Explain how potassium is secreted in the DCT? T[K*] 3Na+ 3Na* 3Na* Aldo Kir4.1-5.1 2K+ 2K+ 2K+ ; Depolarization of membrane >1[CH] MR WNK→SPAK SGK1 NCC NCC NCC HENACE ROMKE GENAC ROMK Maxi-K (-charge) Increased >K+ flow Na+
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![**How is Potassium Secreted in the DCT?**
The diagram illustrates the mechanisms involved in potassium secretion within the Distal Convoluted Tubule (DCT) of the nephron. Here is a detailed description:
1. **Depolarization and Chloride Transport:**
- An increase in potassium concentration \([K^+]\) leads to depolarization of the membrane.
- This depolarization stimulates the Kir4.1–5.1 potassium channels and increases chloride ion \([Cl^-]\) concentration.
- WNK-SPAK signaling pathways are activated, affecting NCC (sodium-chloride cotransporter).
2. **Sodium and Potassium Transport:**
- The Na⁺/K⁺ ATPase pump transports three sodium ions (3Na⁺) out of the cell and brings two potassium ions (2K⁺) into the cell.
- NCC facilitates sodium reabsorption.
3. **Aldosterone's Role:**
- Aldosterone (Aldo) acts on the Mineralocorticoid Receptor (MR) to enhance the expression and activity of the epithelial sodium channel (ENaC), ROMK (renal outer medullary potassium channel), and Maxi-K channels.
- SGK1 enhances activity of these channels, promoting sodium reabsorption and potassium secretion.
4. **Ion Flow and Charge:**
- Sodium reabsorption through ENaC creates a negative charge in the tubular fluid, driving potassium secretion through ROMK and Maxi-K channels.
- Increased fluid flow in the DCT facilitates potassium secretion into the tubular fluid, maintaining electrolyte balance.
This integrated process ensures proper potassium balance and blood pressure regulation.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fea343fce-9161-40c8-a76a-1c966ba86a1f%2F1f0b8956-4eb0-4f77-a965-ce8ed3d6f8c9%2F542vv6_processed.png&w=3840&q=75)
Transcribed Image Text:**How is Potassium Secreted in the DCT?**
The diagram illustrates the mechanisms involved in potassium secretion within the Distal Convoluted Tubule (DCT) of the nephron. Here is a detailed description:
1. **Depolarization and Chloride Transport:**
- An increase in potassium concentration \([K^+]\) leads to depolarization of the membrane.
- This depolarization stimulates the Kir4.1–5.1 potassium channels and increases chloride ion \([Cl^-]\) concentration.
- WNK-SPAK signaling pathways are activated, affecting NCC (sodium-chloride cotransporter).
2. **Sodium and Potassium Transport:**
- The Na⁺/K⁺ ATPase pump transports three sodium ions (3Na⁺) out of the cell and brings two potassium ions (2K⁺) into the cell.
- NCC facilitates sodium reabsorption.
3. **Aldosterone's Role:**
- Aldosterone (Aldo) acts on the Mineralocorticoid Receptor (MR) to enhance the expression and activity of the epithelial sodium channel (ENaC), ROMK (renal outer medullary potassium channel), and Maxi-K channels.
- SGK1 enhances activity of these channels, promoting sodium reabsorption and potassium secretion.
4. **Ion Flow and Charge:**
- Sodium reabsorption through ENaC creates a negative charge in the tubular fluid, driving potassium secretion through ROMK and Maxi-K channels.
- Increased fluid flow in the DCT facilitates potassium secretion into the tubular fluid, maintaining electrolyte balance.
This integrated process ensures proper potassium balance and blood pressure regulation.
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