Estrogens are female sex hormones, the most potent of which is B-estradiol. OH AYA Но B-Estradiol In recent years, chemists have focused on designing and synthesizing molecules that bind to estrogen receptors. One target of this research has been nonsteroidal estrogen antagonists, compounds that interact with estrogen receptors and block the effects of both endogenous and exogenous estrogens. A feature common to one type of nonste- roidal estrogen antagonist is the presence of a 1,2-diphenylethylene with one of the benzene rings bearing a dialkylaminoethoxyl substituent. The first nonsteroidal estrogen antagonist of this type to achieve clinical importance was tamoxifen, now an important drug in the treatment of breast cancer. Tamoxifen has the Z configuration shown here. NMeg A B NMeg ? ОН Tamoxifen Propose reagents for the conversion of A to tamoxifen. Note: The final step in this synthesis gives a mixture of E and Z isomers.

Estrogens are female sex hormones, the most potent of which is B-estradiol. OH AYA Но B-Estradiol In recent years, chemists have focused on designing and synthesizing molecules that bind to estrogen receptors. One target of this research has been nonsteroidal estrogen antagonists, compounds that interact with estrogen receptors and block the effects of both endogenous and exogenous estrogens. A feature common to one type of nonste- roidal estrogen antagonist is the presence of a 1,2-diphenylethylene with one of the benzene rings bearing a dialkylaminoethoxyl substituent. The first nonsteroidal estrogen antagonist of this type to achieve clinical importance was tamoxifen, now an important drug in the treatment of breast cancer. Tamoxifen has the Z configuration shown here. NMeg A B NMeg ? ОН Tamoxifen Propose reagents for the conversion of A to tamoxifen. Note: The final step in this synthesis gives a mixture of E and Z isomers.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

Esters and amides can both be hydrolyzed under acidic or basic conditions. Given the molecule below, choose the 3 products that it would break up into when it is hydrolyzed. A B с OH D H+, heat, H₂O E F HO OH G HO. zu Gigué OH _OH H 1+ I کمه نکنند
Please answer the question for the amines and reactions listed below: A) 00-00 B) (aniline, primary amine) 0.0 C) о یم میں ? The reactions listed above are examples of role of amines in the reaction with the carbonyl group. What is the role of amine would be in the reaction, electrophile or nucleophile? Write the role of amine.
Identify the reaction type. a. hydrolysis (in acid) b. hydration c. dehydration d. acid base e. esterification f. amide synthesis g. hydrolysis (in base)
From the given structures which is(a) amide that will release a secondary amine upon hydrolysis? (b) product of hydrolysis of MSO (c) a tertiary amide and (d) a diketone
Figure 3 shows a substitution reaction between triphenylmethyl chloride and an excess of the base methanamine. What is the minimum mass of this amine required to produce 5.000 grams of the organic product N-methyltriphenylmethanamine? Molar masses are given in Figure 3. [Round the answer to three decimal places. Do not type in the unit. Use a decimal point.] * Do you need to add imidazole to the reaction mixture used in this question to absorb the hydrogen chloride gas produced during the reaction?
are involved in the regulation of glucose metabolism and in control tissue swelling by the control of inflammation, while regulating cellular salt balance between Na+ and K+. a.glucocorticoids, mineralocorticoids b. mineralocorticoids, glucocorticoids c. androgen, estrogen d. estrogen, androgen Which of the following represents an aldonic acid? OH OH но, но OH но —н но Но HO HO H но но H H- -OH -OH H OH H FOH H- -OH- OH HO но HO. OH II III IV V Refer to the structures. Which of the following compounds will react with acetyl chloride to give an amide and ester, respectively? NH2 ÇOOH CH3 он CHO II II IV V The six groups of enzymes are the following: I. Oxidoreductases II. Transferases III. Hydrolases IV. Isomerases V. Lyases VI. Ligases Fill in the blanks: catalyze hydrolysis while catalyze bond formation.
(i)What class of drug is Ranitidine? (ii)If water contains dissolved Ca2+ ions, out of soaps and synthetic detergents, which will you use for cleaning clothes? (iii)Which of the following is an antiseptic? 0.2% phenol, 1% phenol
Fix each molecule in the drawing area below so that it has the structure it would have if it were dissolved in a 0.1 (aq) solution of NaOH 3-hydroxypropanoic acid and 1,3-dihydroxy-2-propanone .
¨ What other types of analgesics are on the market? How does their action compare with aspirin and why are these alternative drugs necessary? Discuss the differences among the following compounds by drawing their structures: Acetylsalicylic acid, Acetaminophen (Paracetamol), Ibuprofen, Paracetamol and Phenacetin.
Illustrate all the locations where 2-methylocta-4,6-dien-1-amine could form hydrogen bonds with water either as a hydrogen donor or as a target (receiver) of hydrogen bonds from water. Do this by drawing bent water molecules as necessary and representing hydrogen bonds between water and the molecule using dashed lines. Be sure it is clear exactly which atoms on each molecule are involved in the hydrogen bonds. If it is not capable of forming hydrogen bonds with water explain why not.