Enlarging chondrocytes within calcifying matrix Spongy bone formation in primary ossification center Formation of compact bone along the diaphysis Removal of spongy bone to form medullary cavity 24 Periosteum S Formation of spongy bone in the secondary ossification centers Bone sheath formation around shaft of cartilage rod Articular cartilage, which will remain throughout life to protect the ends of bones 2004 Spongy bone in the epiphysis Epiphyseal cartilage, where the bone will continue to elongate until adulthood 2007

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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**Endochondral Ossification: Replacement of Cartilage with Bone**

The image sequence illustrates the process of endochondral ossification, where a cartilage model is progressively replaced by bone. This is a key mechanism in the formation and growth of long bones.

1. **Enlarging Chondrocytes within Calcifying Matrix**:
   - Initially, chondrocytes enlarge within the calcifying cartilage matrix, marking the beginning of ossification.

2. **Spongy Bone Formation in Primary Ossification Center**:
   - Osteoblasts start forming spongy bone in the primary ossification center, which typically occurs in the diaphysis (shaft) of the bone.

3. **Formation of Compact Bone along the Diaphysis**:
   - Compact bone begins to form along the outer surface of the diaphysis, offering structural support.

4. **Removal of Spongy Bone to Form Medullary Cavity**:
   - Spongy bone is selectively removed to create the medullary cavity, which will later house bone marrow.

5. **Periosteum and Bone Sheath Formation**:
   - The periosteum, a fibrous membrane, develops around the cartilage rod, facilitating further bone sheath formation.

6. **Formation of Spongy Bone in Secondary Ossification Centers**:
   - Secondary ossification centers develop in the epiphyses (ends of the bone), where spongy bone forms.

7. **Epiphyseal Cartilage and Continued Bone Elongation**:
   - The epiphyseal cartilage (growth plate) remains, allowing bones to continue lengthening until adulthood.

8. **Spongy Bone in the Epiphysis**:
   - The complete ossification of the epiphysis results in the presence of spongy bone at bone ends.

9. **Articular Cartilage**:
   - Articular cartilage remains at the joint surfaces, providing a cushion and reducing friction during movement.

This process is crucial for the growth and development of the skeletal system and ensures bones achieve their proper size and structure in adulthood.
Transcribed Image Text:**Endochondral Ossification: Replacement of Cartilage with Bone** The image sequence illustrates the process of endochondral ossification, where a cartilage model is progressively replaced by bone. This is a key mechanism in the formation and growth of long bones. 1. **Enlarging Chondrocytes within Calcifying Matrix**: - Initially, chondrocytes enlarge within the calcifying cartilage matrix, marking the beginning of ossification. 2. **Spongy Bone Formation in Primary Ossification Center**: - Osteoblasts start forming spongy bone in the primary ossification center, which typically occurs in the diaphysis (shaft) of the bone. 3. **Formation of Compact Bone along the Diaphysis**: - Compact bone begins to form along the outer surface of the diaphysis, offering structural support. 4. **Removal of Spongy Bone to Form Medullary Cavity**: - Spongy bone is selectively removed to create the medullary cavity, which will later house bone marrow. 5. **Periosteum and Bone Sheath Formation**: - The periosteum, a fibrous membrane, develops around the cartilage rod, facilitating further bone sheath formation. 6. **Formation of Spongy Bone in Secondary Ossification Centers**: - Secondary ossification centers develop in the epiphyses (ends of the bone), where spongy bone forms. 7. **Epiphyseal Cartilage and Continued Bone Elongation**: - The epiphyseal cartilage (growth plate) remains, allowing bones to continue lengthening until adulthood. 8. **Spongy Bone in the Epiphysis**: - The complete ossification of the epiphysis results in the presence of spongy bone at bone ends. 9. **Articular Cartilage**: - Articular cartilage remains at the joint surfaces, providing a cushion and reducing friction during movement. This process is crucial for the growth and development of the skeletal system and ensures bones achieve their proper size and structure in adulthood.
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