Emergency endoscopic interventions increase the risk of acute pancreatitis. The initial phase of this disease is associated with the activation of trypsin within the cells of the pancreas. Then the inflammation begins. To protect cells from the action of active proteases, it is necessary to apply an ice pack or a belt with circulating cold water to the anterior abdominal wall. In the initial acute period of pancreatitis (as well as prophylactically before endoscopic procedures), "shock doses" of the synthetic polypeptide gabexate-mesylate and ulinastatin have recently been prescribed. These are new synthetic inhibitors of serine proteases that are not natural polypeptides. Explain why the patient's condition improves with this treatment in the initial phase of pancreatitis Q: specify with which trypsin site these protease inhibitors interact, sketch this process schematically
Emergency endoscopic interventions increase the risk of acute pancreatitis. The initial phase of this disease is associated with the activation of trypsin within the cells of the pancreas. Then the inflammation begins. To protect cells from the action of active proteases, it is necessary to apply an ice pack or a belt with circulating cold water to the anterior abdominal wall. In the initial acute period of pancreatitis (as well as prophylactically before endoscopic procedures), "shock doses" of the synthetic polypeptide gabexate-mesylate and ulinastatin have recently been prescribed. These are new synthetic inhibitors of serine proteases that are not natural polypeptides. Explain why the patient's condition improves with this treatment in the initial phase of pancreatitis
Q: specify with which trypsin site these protease inhibitors interact, sketch this process schematically
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