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E. Histidine is an amino acid with three titratable groups: an -NH," group (pK, = 9.2), a -COOH group (pK, = 1.8), and an imidazole (amine- like) group (pK, = 6.0). The titration curve for histidine is shown below with four points highlighted. (a) Identify which point on the titration curve corresponds to the pK, for each of the titratable groups, and which point corresponds to the pl. Explain your choices. (b) Calculate the value of pl for histidine. 14 12 10 6. 4 2- 2 3 Moles "OH added per mole histidine на

E. Histidine is an amino acid with three titratable groups: an -NH," group (pK, = 9.2), a -COOH group (pK, = 1.8), and an imidazole (amine- like) group (pK, = 6.0). The titration curve for histidine is shown below with four points highlighted. (a) Identify which point on the titration curve corresponds to the pK, for each of the titratable groups, and which point corresponds to the pl. Explain your choices. (b) Calculate the value of pl for histidine. 14 12 10 6. 4 2- 2 3 Moles "OH added per mole histidine на

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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E. Histidine is an amino acid with three titratable groups: an -NH," group (pK, = 9.2), a -COOH group (pK, = 1.8), and an imidazole (amine- like) group (pK, = 6.0). The titration curve for histidine is shown below with four points highlighted. (a) Identify which point on the titration curve corresponds to the pK, for each of the titratable groups, and which point corresponds to the pl. Explain your choices. (b) Calculate the value of pl for histidine. 14 12 10 6. 4 2- 2 3 Moles "OH added per mole histidine на
Transcribed Image Text:E. Histidine is an amino acid with three titratable groups: an -NH," group (pK, = 9.2), a -COOH group (pK, = 1.8), and an imidazole (amine- like) group (pK, = 6.0). The titration curve for histidine is shown below with four points highlighted. (a) Identify which point on the titration curve corresponds to the pK, for each of the titratable groups, and which point corresponds to the pl. Explain your choices. (b) Calculate the value of pl for histidine. 14 12 10 6. 4 2- 2 3 Moles "OH added per mole histidine на
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