During the synthesis of the antiasthmatic drug montelukast (Singulair), a silyl ether protecting group is used to mask the reactivity of an OH group. The silyl group chosen is the tert-butyldimethylsilyl (TBS) group. Draw the product of the following transforma- tion, assuming the TBS-Cl reagent reacts only once with the starting material. Briefly explain your answer. CH3 НО H3C-C-CH3 H3C-Si-CH3 CH3 H3C OH Cl, CI Imidazole (base) DMF/CH,Cl,

During the synthesis of the antiasthmatic drug montelukast (Singulair), a silyl ether protecting group is used to mask the reactivity of an OH group. The silyl group chosen is the tert-butyldimethylsilyl (TBS) group. Draw the product of the following transforma- tion, assuming the TBS-Cl reagent reacts only once with the starting material. Briefly explain your answer. CH3 НО H3C-C-CH3 H3C-Si-CH3 CH3 H3C OH Cl, CI Imidazole (base) DMF/CH,Cl,

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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