drug is infused intravenously (IV) for treatment of a particular disease. The infusion rate of the drug is k0 = 200 mg/hr. The volume of the body fluid V = 16 liters. The drug is excreted (removed) through the kidneys at rate ke = 0.3/hr, proportional to the concentration of the drug in the body fluids. How much is the maximum concentration of the drug in the body in the steady state in mg/l?

drug is infused intravenously (IV) for treatment of a particular disease. The infusion rate of the drug is k0 = 200 mg/hr. The volume of the body fluid V = 16 liters. The drug is excreted (removed) through the kidneys at rate ke = 0.3/hr, proportional to the concentration of the drug in the body fluids. How much is the maximum concentration of the drug in the body in the steady state in mg/l?

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter9: Parenteral Medication Labels And Dosage Calculation

Section: Chapter Questions

Problem 7.7P

See similar textbooks

Similar questions

In the preparation of an intravenous infusion, a vial containing 100 mg of drug is diluted to 2 mL with sodium chloride for injection. Then, the contents of the vial are added to 100 mL of an infusion solution. Calculate the final strength of the drug infusion in percentage strength (% w/v)
200 mg of drug is given IV, plasma drug concentration is 70 mg/L. Calculate the Vd? Where most of the drug is distributed to? Note: Volume of Distribution (L) = Amount of drug in the body (mg) / Plasma concentration of drug (mg/L). O a. Vd=14000 L, drug is mostly outside of plasma, distributed to tissues O b. Vd=2.8 L, drug is mostly outside of plasma, distributed to tissues OC. Vd =0.35 L, drug is mostly in plasma Od. Vd=2.8 L, drug is mostly in plasma O e. Vd =0.35 L, drug is mostly outside of plasma, distributed to tissues
A 79 kg man is admitted to hospital following a suspected overdose of drug G. When he is admitted to hospital on the 3rd October at 23:00 his plasma concentration of drug G is 12 mg/mL. Given that the half-life (t½) of drug G is 10.5 hours. What would you expect his plasma concentration of drug G to be at 17:00 on the 5th October? Give the answer in microg/ml. (You may assume that the distribution is complete and the elimination is described by a 1storder process.)
Choose the correct answer.
Based on the following information, what is the fraction of the drug that is excreted unchanged in the urine? CLR = 11.2 L/hr Dose = 1000 mg AUC, = 27.9 mg/L x hr %3D
Drug Clearance For example, if the ClT of penicillin is 15mL/min in a patient and penicillin has a VD of 12 L, then from the clearance definition, 15 mL of the 12 L would be cleared of drug per minute. Formula: ClT = Elimination Rate (microgram/min) Plasma concentration (microgram/mL)
A 30-year-old female patient with uncontrolled hypertension is suspected by an investi- gating endocrinologist of having Conn's syndrome. Results of routine biochemistry were (reference ranges are given in brackets): Sodium Potassium Urea Creatinine Alkaline phosphatase Alanine aminotransferase Albumin Bilirubin Calcium 146 mmol/L 2.1 mmol/L 7.2 mmol/L 146 μmol/L 290 IU/L 20 IU/L 49 g/L 8 μmol/L 2.19 mmol/L (135-145) (3.5-5.0) (3.5-6.6) (70-150) (95-320) (5-42) (35-50) (<17) (2.12-2.62) (a) Are any of the electrolyte concentrations abnormal, and if so what condition is suggested? (b) What further biochemistry investigations would you undertake? Explain your reasoning.
*A drug is ordered at 0.3 mg/kg/min. If the patient weighs 148 pounds, find the dosage rate in mg/min. * An IVPB is infusing at 0.5 mcg/min. The solution concentration is 50 mcg in 100 mL NS. What is the pump setting in mL/h? * Calculate the daily fluid maintenance and the hourly flow rate for a child who weighs 17 kg.
A physician orders lidocaine 100 mg in D5 How many drops per minute will be administered? sgad to ini yasm voH A physician orders epinephrine 50 mcg/min to be administered from fluids that contain epinephrine 5 mg in D5LR 500 mL. The drop factor is 20 gtt/mL. How many minutes will it take for the fluids to infuse? What is the rate of infusion in drops per minute? What is the flow rate in milliliters per hour? after 300 mL had infused? Luhte reserved.
A 68-year-old lady with bowel cancer who had been admitted to hospital following a fall had a persistent low plasma sodium including the following plasma results (refer- ence ranges are given in brackets): Sodium Potassium Urea Creatinine Glucose Osmolality 120 mmol/L 3.9 mmol/L 3.4 mmol/L 53 μmol/L 5.2 mmol/L 255 mOsm/kg (135-145) (3.5-5.0) (3.5-6.6) (70-150) (3.5-5.5) (285-305) In this patient, the urine volume was low and relatively concentrated, the urine osmo- lality was 374 mOsm/kg and its sodium concentration was 75 mmol/L. Comment on these results.
A patient with ventricular fibrillation is prescribed with bretylium 5 mcg/kg/minute. The medication comes mixed 50 mg in 50 mL of 0.9 % normal saline. The patient’s weight is 170 lbs. How much of the medication will you administer per hour?mls/hour?
A 72-year-old adult patient who weighs 78 kg is prescribed by the doctor “Potassium Chloride 40meq in 1L to run for 8 hours” via the peripheral line for a potassium level of 3.3 mEq/L that was drawn this morning. Note: 10 mEq of potassium chloride increases serum potassium levels by approximately 0.1 mEq/.L The concentration of potassium for intravenous administration via a peripheral line should not exceed 40mmol / 500 mL 10 mEq/hr maximum infusion rate; not to exceed 200 mEq dose/24hr Administration rates above 20mmol/hour require cardiac monitoring. How much will the order medication “Potassium Chloride 40meq in 1L to run for 8 hours” raise the patient's potassium level in a day? Is it still within the normal potassium serum levels, which is 3.5–5.0 mEq/L? Does the order comply with the maximum concentration of potassium to be administered peripherally? Does the order’s infusion rate do not exceed the standard maximum infusion rate? Does the order require cardiac monitoring?