Draw two derivatives of the penicillamine analogue, one with a bioisosteric replacement for the carboxylic acid in penicillamine, and one derivative containing a bioisosteric replacement for the amide group.

Show how to convert amines to other functional groups, and devise multistepsyntheses using amines as starting materials and intermediates

In the 1880's, Acetanilide, sold under the name Antifebrin, was widely used as a pain reliever and fever reducer. However, it had many adverse side effects, including cyanosis as a result of methemoglobinemia. The toxic side effects were the result of a small portion of acetanilide being hydrolyzed to aniline. Acetanilide was discontinued and replaced with phenacetin. Later studies show that both acetanilide and phenacetin are metabolized to acetaminophen. This metabolite, which we know as Tylenol, is responsible for the analgesic and antipyretic properties. Part 1: Show a detailed arrow pushing mechanism of the acid catalyzed hydrolysis of acetanilide to aniline Part 2: Propose a synthesis of Acetaminophen from phenol NH NH NH Phenacetin inophen Acetanilide Attach File Browse Local Files Browse Content Collection

The common precursor of amine hormones is the aromatic amino acid

Indicate whether the following statement is true or false. Aliphatic amines are more basic than ammonia, whereas aromatic amines are less basic than ammonia. When amines are reacted with bases, they form ammonium salts. Benzenesulfonyl chloride or p-toluenesulfonylchloride give N-substituted sulfonamides with primary and secondary amines. Derivative of primary amines is insoluble in dilute NaOH

Explain why a secondary amine forms a nitrosamine rather than a diazonium ion when it reacts with anitrosonium ion.

Most drugs containing amine groups are not administeredas the amine but rather as the ammonium salt. Can yousuggest a reason why?

Differentiate between imine and enamine formation?

Which compouhd is a primiary amine with the formula CSH13N7 HN HN II NH2 IV V. Il and V

Which type of amine is phentermine?   a)  a primary aliphatic amine   b)  a primary aromatic amine   c)  a tertiary aliphatic amine   d)  a tertiary aromatic amine