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Draw the major product of this aldol addition reaction. Ignore inorganic byproducts. O + 1. NaOH 2. Neutralizing work-up Drawing Q Atoms, Bonds and Rings Charges Drag Undo Remove

Draw the major product of this aldol addition reaction. Ignore inorganic byproducts. O + 1. NaOH 2. Neutralizing work-up Drawing Q Atoms, Bonds and Rings Charges Drag Undo Remove

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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**Aldol Addition Reaction: Major Product Formation** **Objective:** Draw the major product of the given aldol addition reaction, disregarding any inorganic byproducts. **Reactants:** 1. Cyclohexanone (a six-membered carbon ring with one ketone group). 2. Pentane-2,4-dione (a linear carbon chain with two ketone groups at the 2nd and 4th positions). **Reaction Conditions:** 1. Use of NaOH (sodium hydroxide) as a base. 2. Followed by a neutralizing work-up step. **Reaction Process:** The aldol addition involves the deprotonation of an α-hydrogen from one of the carbonyl groups by the base (NaOH) to form an enolate ion. This enolate then attacks the electrophilic carbonyl carbon of the other molecule, forming a β-hydroxy ketone. Subsequent dehydration may lead to the formation of a more stable α,β-unsaturated ketone. **Diagram Explanation:** - The given chemical structure illustrates the major product formed in this reaction. It consists of: - A central cyclohexane ring attached at the α-position to an unsaturated carbon chain. - Two ketone groups in the resulting compound after the aldol reaction has occurred. This depiction shows how the reacted molecules are aligned to form the aldol addition product, highlighting the new double bond formed between the carbon atoms adjacent to the ketone group on the cyclohexane ring.
Transcribed Image Text:**Aldol Addition Reaction: Major Product Formation** **Objective:** Draw the major product of the given aldol addition reaction, disregarding any inorganic byproducts. **Reactants:** 1. Cyclohexanone (a six-membered carbon ring with one ketone group). 2. Pentane-2,4-dione (a linear carbon chain with two ketone groups at the 2nd and 4th positions). **Reaction Conditions:** 1. Use of NaOH (sodium hydroxide) as a base. 2. Followed by a neutralizing work-up step. **Reaction Process:** The aldol addition involves the deprotonation of an α-hydrogen from one of the carbonyl groups by the base (NaOH) to form an enolate ion. This enolate then attacks the electrophilic carbonyl carbon of the other molecule, forming a β-hydroxy ketone. Subsequent dehydration may lead to the formation of a more stable α,β-unsaturated ketone. **Diagram Explanation:** - The given chemical structure illustrates the major product formed in this reaction. It consists of: - A central cyclohexane ring attached at the α-position to an unsaturated carbon chain. - Two ketone groups in the resulting compound after the aldol reaction has occurred. This depiction shows how the reacted molecules are aligned to form the aldol addition product, highlighting the new double bond formed between the carbon atoms adjacent to the ketone group on the cyclohexane ring.
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