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Draw the complete structure of the trinucleotide deoxyribo-oligonucleotide that is complementary to 5'dTdGdA3'. Draw this completely, showing all atoms of all parts of the structure.

Draw the complete structure of the trinucleotide deoxyribo-oligonucleotide that is complementary to 5'dTdGdA3'. Draw this completely, showing all atoms of all parts of the structure.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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### Understanding DNA Complementarity #### Instruction: Draw the complete structure of the trinucleotide deoxyribo-oligonucleotide that is complementary to 5'dTdGdA3'. Draw this completely, showing all atoms of all parts of the structure. #### Explanation: To answer this question, we need to understand the basics of DNA complementarity. DNA strands pair through complementary base pairing: - Adenine (A) pairs with Thymine (T) - Guanine (G) pairs with Cytosine (C) Given the sequence 5'dTdGdA3', we need to determine its complementary sequence. #### Step-by-Step Solution: 1. **Identify the given sequence**: 5'dTdGdA3' 2. **Find the complementary bases**: - The complement of T (Thymine) is A (Adenine). - The complement of G (Guanine) is C (Cytosine). - The complement of A (Adenine) is T (Thymine). 3. **Write the complementary sequence**: Read from 3' to 5' (since it is complementary): - Original: 5'dTdGdA3' - Complement: 3'dAdCdT5' 4. **Draw the molecular structures**: Each nucleotide is composed of a deoxyribose sugar, a phosphate group, and a nitrogenous base (A, T, G, or C). #### Detailed Explanation of Drawing: - **Phosphate Group**: Attach to the 5' carbon of deoxyribose. - **Deoxyribose Sugar**: A five-carbon sugar with carbons labeled 1' to 5'. - **Nitrogenous Bases**: A (adenine), C (cytosine), and T (thymine). **Diagrams**: 1. **Adenine Complementary to Thymine**: - Thymine from the original pair with Adenine on the complementary strand. - Show hydrogen bonds between them. 2. **Cytosine Complementary to Guanine**: - Guanine from the original pair with Cytosine on the complementary strand. - Show hydrogen bonds between them. 3. **Thymine Complementary to Adenine**: - Adenine from the original pair with Thymine on the complementary strand.
Transcribed Image Text:### Understanding DNA Complementarity #### Instruction: Draw the complete structure of the trinucleotide deoxyribo-oligonucleotide that is complementary to 5'dTdGdA3'. Draw this completely, showing all atoms of all parts of the structure. #### Explanation: To answer this question, we need to understand the basics of DNA complementarity. DNA strands pair through complementary base pairing: - Adenine (A) pairs with Thymine (T) - Guanine (G) pairs with Cytosine (C) Given the sequence 5'dTdGdA3', we need to determine its complementary sequence. #### Step-by-Step Solution: 1. **Identify the given sequence**: 5'dTdGdA3' 2. **Find the complementary bases**: - The complement of T (Thymine) is A (Adenine). - The complement of G (Guanine) is C (Cytosine). - The complement of A (Adenine) is T (Thymine). 3. **Write the complementary sequence**: Read from 3' to 5' (since it is complementary): - Original: 5'dTdGdA3' - Complement: 3'dAdCdT5' 4. **Draw the molecular structures**: Each nucleotide is composed of a deoxyribose sugar, a phosphate group, and a nitrogenous base (A, T, G, or C). #### Detailed Explanation of Drawing: - **Phosphate Group**: Attach to the 5' carbon of deoxyribose. - **Deoxyribose Sugar**: A five-carbon sugar with carbons labeled 1' to 5'. - **Nitrogenous Bases**: A (adenine), C (cytosine), and T (thymine). **Diagrams**: 1. **Adenine Complementary to Thymine**: - Thymine from the original pair with Adenine on the complementary strand. - Show hydrogen bonds between them. 2. **Cytosine Complementary to Guanine**: - Guanine from the original pair with Cytosine on the complementary strand. - Show hydrogen bonds between them. 3. **Thymine Complementary to Adenine**: - Adenine from the original pair with Thymine on the complementary strand.
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