To convert animal dose to human dose, the following formula may be applied: Human dose (m) = Animal dose mg (human weight\ animal weight) 2/3 d The following formula should be used to calculate the incremental risk (Pexcess) at a given dose: Pdose - Pcontrol Pexcess 1 - Pcontrol where Pcontrol is the risk at zero dose of the chemical. The average female mice weight is assumed 0.05kg. Dose in female mice % with liver cancer mg/d 0.00 2.6 0.08 4.9 0.15 9.6 0.20 11.7 0.30 16.4 0.38 20.1 0.45 22.6

To convert animal dose to human dose, the following formula may be applied: Human dose (m) = Animal dose mg (human weight\ animal weight) 2/3 d The following formula should be used to calculate the incremental risk (Pexcess) at a given dose: Pdose - Pcontrol Pexcess 1 - Pcontrol where Pcontrol is the risk at zero dose of the chemical. The average female mice weight is assumed 0.05kg. Dose in female mice % with liver cancer mg/d 0.00 2.6 0.08 4.9 0.15 9.6 0.20 11.7 0.30 16.4 0.38 20.1 0.45 22.6

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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