Disubstituted amides often have lower boiling points than unsubstituted amides. What is the main reason for this observation? Disubstituted amides can form more hydrogen bonds than unsubstituted amides. Disubstituted amides usually have higher molecular weights than unsubstituted amides. Disubstituted amides have less branching than unsubstituted amides. Disubstituted amides have more branching than unsubstituted amides. Disubstituted amides cannot form hydrogen bonds whereas unsubstituted amides can form the hydrogen bonds.

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Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.