Deuterium (D) is an isotope of H. Both D and H have one proton and one electron; H has no neutrons and D has one. Consequently, D and H have nearly identical behavior, but they can be distinguished from each other experimentally due to their different masses. Therefore, replacing an H with a D in a molecule-deuterium isotope labeling-can provide valuable information about a mechanism. With this in mind, how would you synthesize each of the following deuterium-labeled compounds from the analogous unlabeled compound, using D,0 as your only source of deuterium? Hint: You will have to use two separate proton transfer reactions to synthesize each one. (a) (b) (c) OD D.

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Deuterium (D) is an isotope of H. Both D and H have one proton and one electron; H has no neutrons and D has one.
Consequently, D and H have nearly identical behavior, but they can be distinguished from each other experimentally
due to their different masses. Therefore, replacing an H with a D in a molecule-deuterium isotope labeling-can
provide valuable information about a mechanism. With this in mind, how would you synthesize each of the following
deuterium-labeled compounds from the analogous unlabeled compound, using D,0 as your only source of deuterium?
Hint: You will have to use two separate proton transfer reactions to synthesize each one.
(a)
(b)
(c)
OD
D.
Transcribed Image Text:Deuterium (D) is an isotope of H. Both D and H have one proton and one electron; H has no neutrons and D has one. Consequently, D and H have nearly identical behavior, but they can be distinguished from each other experimentally due to their different masses. Therefore, replacing an H with a D in a molecule-deuterium isotope labeling-can provide valuable information about a mechanism. With this in mind, how would you synthesize each of the following deuterium-labeled compounds from the analogous unlabeled compound, using D,0 as your only source of deuterium? Hint: You will have to use two separate proton transfer reactions to synthesize each one. (a) (b) (c) OD D.
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