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- Write about Oxford–AstraZeneca COVID-19 vaccine (Covishield) You must include the following information Chemistry of the drugs: Structure, physicochemical properties, (log P, pKa, & stereochemistry) and chemical properties and stability. Mechanism of action: (including the possible drug target interactions) in CoVid-19 Pharmacokinetic: Absorption, distribution (% plasma binding), chemical basis of metabolic pathways and elimination Pharmacological properties including side effect, ADR, drug interaction, precautions, dose and dosage forms Stability and storage conditions, as well as Brand names1 of 16 Data from an experiment is shown in the figure below. In the experiment, murine cells were treated with a specific a ligand that activates receptor R. In some cases, the cells were exposed to one of two drugs (X or Y) as well as the ligand or were left untreated (UT). After 30 minutes of treatment, the cells were lysed with a detergent-based buffer to release the soluble membrane, cyosolic and nuclear proteins. Samples from each cell extract were run (in duplicate) by SDS-PAGE (SDS-polyacrylamide gel electrophoresis) in order to separate the proteins by molecular mass (size). The separated proteins were then transferred to a nitrocellulose membrane which was then probed with different antibodies in a western blotting procedure to detect specific phosphorylated proteins or total proteins. If present in the cell extract, these proteins appear as a dark band in the relevant western blot image within the figure. Drug X Drug Y UT Ligand Ligand Ligand Western blotting antibodies…Explain the effect of COM-blockers on bacterial transformation and their application in controlling drug resistance.
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