Data: Rate difference per 1000 PY: _-11.97____; 95% CI _-14.93____ to __-9.01___ HR: _50____; 95% CI __0.42___ to _0.59____ Which statement is the most correct interpretation of the risk of pooled GI bleeding or ICH? Apixaban resulted in a statistically significant decrease in GI bleeding or ICH compared to rivaroxaban Apixaban resulted in a statistically significant increase in GI bleeding or ICH compared to rivaroxaban There was no statistically significant difference in GI bleeding or ICH between apixaban and rivaroxaban.
Data:
- Rate difference per 1000 PY: _-11.97____; 95% CI _-14.93____ to __-9.01___
- HR: _50____; 95% CI __0.42___ to _0.59____
Which statement is the most correct interpretation of the risk of pooled GI bleeding or ICH?
-
- Apixaban resulted in a statistically significant decrease in GI bleeding or ICH compared to rivaroxaban
- Apixaban resulted in a statistically significant increase in GI bleeding or ICH compared to rivaroxaban
- There was no statistically significant difference in GI bleeding or ICH between apixaban and rivaroxaban.
The correct interpretation of the provided information is:
Apixaban resulted in a statistically significant decrease in GI bleeding or ICH compared to rivaroxaban.
Here's the rationale:
"rate difference per 1000 PY: -11.97" indicates that there were 11.97 fewer cases of GI bleeding or ICH per 1000 person-years (PY) among those taking apixaban compared to rivaroxaban. A negative rate difference suggests a decrease in events.
"HR: 50 95% CI 0.42 to 0.59" The Hazard Ratio (HR) of 0.50 with a 95% confidence interval (CI) from 0.42 to 0.59 also indicates a significant reduction in risk. An HR below 1 suggests a decreased risk in the group taking apixaban.
The combined information from the rate difference and the hazard ratio both support the conclusion that apixaban is associated with a statistically significant decrease in GI bleeding or ICH compared to rivaroxaban.
Step by step
Solved in 3 steps
