d) NaOH/H;O & heptane OEt OEt Aliquat 336 1) Mg in ether e) H. 2) 3) H*/H2O f) 1) H20, H2SO4, A NH 2) NH,OH

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter18: Functional Derivatives Of Carboxylic Acids
Section: Chapter Questions
Problem 18.69P
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What is the major product of these reactions? Could you explain how you got the products?

### Image Transcription for Educational Website

#### Chemical Reactions

**d)** A chemical reaction involving:
- A ketone compound: 
  - ![attach molecule image] with a formula containing a ketone group.
- Mixed with a diethyl phosphorochloridate compound: 
  - ![attach molecule image] a triphosphate ester.
- This reaction proceeds using:
  - **NaOH/H₂O & heptane** as the medium.
  - **Aliquat 336** as the phase-transfer catalyst.

---

**e)** A multi-step reaction involving:
1. Starting with an alkyl halide:
   - ![attach molecule image] with a chlorine atom.
2. Reacted with **Mg in ether** to form a Grignard reagent.
3. Sequential reaction:
   - **H** indicates acid-workup with an aromatic ketone.
   - [second structure] **H⁺/H₂O** for aqueous acidic workup.

---

**f)** A two-step reaction involving:
1. Starting with an amide compound:
   - ![attach molecule image] with a methyl and an aromatic group.
2. Reactions proceed with:
   - **H₂O, H₂SO₄, Δ** indicating hydrolysis under acidic and heat conditions.
3. Finally treated with:
   - **NH₄OH** for neutralization or a modification step.

---

These chemical processes illustrate important methods in organic synthesis, including Grignard reaction formation and hydrolysis under acidic conditions, useful in constructing complex organic molecules.
Transcribed Image Text:### Image Transcription for Educational Website #### Chemical Reactions **d)** A chemical reaction involving: - A ketone compound: - ![attach molecule image] with a formula containing a ketone group. - Mixed with a diethyl phosphorochloridate compound: - ![attach molecule image] a triphosphate ester. - This reaction proceeds using: - **NaOH/H₂O & heptane** as the medium. - **Aliquat 336** as the phase-transfer catalyst. --- **e)** A multi-step reaction involving: 1. Starting with an alkyl halide: - ![attach molecule image] with a chlorine atom. 2. Reacted with **Mg in ether** to form a Grignard reagent. 3. Sequential reaction: - **H** indicates acid-workup with an aromatic ketone. - [second structure] **H⁺/H₂O** for aqueous acidic workup. --- **f)** A two-step reaction involving: 1. Starting with an amide compound: - ![attach molecule image] with a methyl and an aromatic group. 2. Reactions proceed with: - **H₂O, H₂SO₄, Δ** indicating hydrolysis under acidic and heat conditions. 3. Finally treated with: - **NH₄OH** for neutralization or a modification step. --- These chemical processes illustrate important methods in organic synthesis, including Grignard reaction formation and hydrolysis under acidic conditions, useful in constructing complex organic molecules.
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