Controlled drug delivery' was mentioned in the positive outcomes. If islet beta cells are encapuslated within the TPU scaffold, how will it be released over time to integrate directly to the pancreas? In posible negative outcomes 'Mechanical problems' was mentioned so can you explain in detail the mechanical wear and tear that occurs and which areas of the scaffold will be most affected by hydrostatic pressure and how the TPU material would react. What preventative measures can be taken to prevent the scaffold from losing its structural integrity?

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Substance Abuse

Substance abuse refers to the use of illegal drugs in excessive quantities, as well as the misuse of legal substances such as prescription or over-the-counter pharmaceuticals or alcohol for purposes other than those intended. Drug addiction, also known as substance use disorder, is a disease that affects the brain and behavior of a person. It leads to a failure to control the use of any drug or prescription, legal or illegal.