Consider two weak acids, with pKa values of 1.8 and 4.5. Calculate the fraction binding of each for thecase when pH = pKa, and the fraction binding when pH = 6.0. When we say the pH = pKa at the midpoint of a titration curve, we are assuming slight dissociation ofweak acids. What does your answer to question 1 say about the validity of this assumption?

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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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  1. Consider two weak acids, with pKa values of 1.8 and 4.5. Calculate the fraction binding of each for the
    case when pH = pKa, and the fraction binding when pH = 6.0.
  2. When we say the pH = pKa at the midpoint of a titration curve, we are assuming slight dissociation of
    weak acids. What does your answer to question 1 say about the validity of this assumption?
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