Consider the following reaction sequence for the synthesis of Ibuprofen: CO₂Et 1) NaOEt A 2) (EtO)₂C=O 1) NaOEt 2) CH3l B H3O+ Δ .CO,H Ibuprofen 2.1 Propose a reaction mechanism for the formation of intermediate A. 2.2 Propose a reaction mechanism for the formation of intermediate B.

Consider the following reaction sequence for the synthesis of Ibuprofen: CO₂Et 1) NaOEt A 2) (EtO)₂C=O 1) NaOEt 2) CH3l B H3O+ Δ .CO,H Ibuprofen 2.1 Propose a reaction mechanism for the formation of intermediate A. 2.2 Propose a reaction mechanism for the formation of intermediate B.

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter11: Ethers, Epoxides, And Sulfides

Section: Chapter Questions

Problem 11.37P: Following are the steps in the industrial synthesis of glycerin. Provide structures for all...

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Question

Consider the following reaction sequence for the synthesis of Ibuprofen:
CO₂Et
1) NaOEt
A
2) (EtO)₂C=O
1) NaOEt
2) CH3l
B
H3O+
Δ
.CO,H
Ibuprofen
2.1 Propose a reaction mechanism for the formation of intermediate A.
2.2 Propose a reaction mechanism for the formation of intermediate B.

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