Homework Help is Here – Start Your Trial Now!
Science
Biology
Congenital adrenal hyperplasia is a disease characterized by an enlarged adrenal gland, aldosterone and cortisol deficiency, and excess testosterone production. In humans, congenital adrenal hyperplasia occurs at a frequency of 41 in 5000 births, and is one of the most common inborn errors of metabolism. This disease results from a deficiency in one of the enzymes involved in steroidogenesis. Approximately 95% of the affected cases have been reported to be due to a defect only in the P-450(C21) gene coding for the enzyme 21 hydroxylase (Higashi et al. 1986). Higashi et al. (1986) found that three critical mutations were found in one of the two genes coding for 21-hydroxylase to render the gene nonfunctional. The following is a partial DNA sequence from one of the 21-hydroxylase genes where one of the three most common mutations occurs. For the following piece of normal DNA from the 21-hydroxylase gene, fill in the corresponding mRNA codons, and amino acids, and then do the same for the mutatec sequence below it. See Fig. 4-17 in Silverthorn for the genetic code. normal DNA sequence CTC

Congenital adrenal hyperplasia is a disease characterized by an enlarged adrenal gland, aldosterone and cortisol deficiency, and excess testosterone production. In humans, congenital adrenal hyperplasia occurs at a frequency of 41 in 5000 births, and is one of the most common inborn errors of metabolism. This disease results from a deficiency in one of the enzymes involved in steroidogenesis. Approximately 95% of the affected cases have been reported to be due to a defect only in the P-450(C21) gene coding for the enzyme 21 hydroxylase (Higashi et al. 1986). Higashi et al. (1986) found that three critical mutations were found in one of the two genes coding for 21-hydroxylase to render the gene nonfunctional. The following is a partial DNA sequence from one of the 21-hydroxylase genes where one of the three most common mutations occurs. For the following piece of normal DNA from the 21-hydroxylase gene, fill in the corresponding mRNA codons, and amino acids, and then do the same for the mutatec sequence below it. See Fig. 4-17 in Silverthorn for the genetic code. normal DNA sequence CTC

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
Question
Bookmarks People Tab Window Help O Quiz: Enzyme lab critical thinkir x Zoom Congenital adrenal hyperplasia is a disease characterized by an enlarged adrenal gland, aldosterone and cortisol deficiency, and excess testosterone production. In humans, congenital adrenal hyperplasia occurs at a frequency of 41 in 5000 births, and is one of the most common inborn errors of metabolism. This disease results from a deficiency in one of the enzymes involved in steroidogenesis. Approximately 95% of the affected cases have been reported to be due to a defect only in the P-450(C21) gene coding for the enzyme 21 hydroxylase (Higashi et al. 1986). Higashi et al. (1986) found that three critical mutations were found in one of the two genes coding for 21-hydroxylase to render the gene nonfunctional. The following is a partial DNA sequence from one of the 21-hydroxylase genes where one of the three most common mutations occurs. For the following piece of normal DNA from the 21-hydroxylase gene, fill in the corresponding mRNA codons, and amino acids, and then do the same for the mutated sequence below it. See Fig. 4-17 in Silverthorn for the genetic code. GCT GAC GTC CTC CTC normal DNA sequence normal MRNA sequence normal amino acid sequence HIGASHI, Y., H. YOSHIOKA, M. YAMANE, O. GOTOHT, & Y. Fujm-KURIYAMA. 1986. Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: A pseudogene and a genuine gene. Proc. Nati. Acad. Sci. 83: 2841-2845 Edit View Insert Format Tools Table 12pt v Paragraph В I 40 FEB tv W 11 MacBook Air
Transcribed Image Text:Bookmarks People Tab Window Help O Quiz: Enzyme lab critical thinkir x Zoom Congenital adrenal hyperplasia is a disease characterized by an enlarged adrenal gland, aldosterone and cortisol deficiency, and excess testosterone production. In humans, congenital adrenal hyperplasia occurs at a frequency of 41 in 5000 births, and is one of the most common inborn errors of metabolism. This disease results from a deficiency in one of the enzymes involved in steroidogenesis. Approximately 95% of the affected cases have been reported to be due to a defect only in the P-450(C21) gene coding for the enzyme 21 hydroxylase (Higashi et al. 1986). Higashi et al. (1986) found that three critical mutations were found in one of the two genes coding for 21-hydroxylase to render the gene nonfunctional. The following is a partial DNA sequence from one of the 21-hydroxylase genes where one of the three most common mutations occurs. For the following piece of normal DNA from the 21-hydroxylase gene, fill in the corresponding mRNA codons, and amino acids, and then do the same for the mutated sequence below it. See Fig. 4-17 in Silverthorn for the genetic code. GCT GAC GTC CTC CTC normal DNA sequence normal MRNA sequence normal amino acid sequence HIGASHI, Y., H. YOSHIOKA, M. YAMANE, O. GOTOHT, & Y. Fujm-KURIYAMA. 1986. Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: A pseudogene and a genuine gene. Proc. Nati. Acad. Sci. 83: 2841-2845 Edit View Insert Format Tools Table 12pt v Paragraph В I 40 FEB tv W 11 MacBook Air
Expert Solution
steps

Step by step

Solved in 2 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Metabolism
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS