Computational Approaches to studying or mitigating of tuberculios please list the steps and a relaible source for your answer
Computational Approaches to studying or mitigating of tuberculios
please list the steps and a relaible source for your answer
Tuberculosis is a disease caused by bacteria called Mycobacterium tuberculosis.The bacteria which found in TB it affects lungs badly.The bacteria spread when an infected person coughs or sneezes.Almost 1.3 million die of TB worldwide each year.A key steps in developing effective vaccines and possibly shorter treatment regimens is the ability to identify biomarkers that correlate prognosis and progression to infection.To identifying biomarker for TB is an ongoing challenge in developing immunological correlates of infection outcome and protection so we moved towards machine learning techniques were used to interrogate the experimental Non-human primates(NHP) datasets without identifying any potential TB biomarker.In parallel,we use extensive novel NHP datasets to build and calibrate a multi-organ computational model that combines what is occurring at the sites of infection at a single granuloma scale with blood level readout that can be tracked in monkeys and humans.Then generated a large in silico repository of in silico granulomas coupled to lymph node and blood dynamics and developed an in silico tool to scale granuloma level results to a full host scale to identify what best predicts Mycobacterium TB infection outcomes.The analysis of in silico blood measures identifies Mtb-specific frequencies of effector T cell phenotypes at various time points post infection as promising indicators of infection outcome.so emphasize that pairing at wetlab and computational approaches holds great promise to accelerate TB biomarker discovery.we show how pairing computer modelling,statistics and mathematics with dataset derived from NHP studies can accelerates biomarker discovery and offer a new approach to identifying correlates of protection that will be useful in clinical practice.
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