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Complete the following syntheses by providing the reagents and conditions at the reaction arrows. iple steps: 1) do this.... 2) then do this, etc. )

Complete the following syntheses by providing the reagents and conditions at the reaction arrows. iple steps: 1) do this.... 2) then do this, etc. )

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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**Synthesis Problems for Educational Purposes** **Problem 6**: Complete the following syntheses by providing the reagents and conditions at the reaction arrows. (Multiple steps: 1) do this... 2) then do this, etc.) **Synthesis Pathways and Diagrams:** 1. **First Synthesis**: - Starting Material: Benzene ring with a Bromine (Br) substituent. - First Reaction: - Reagent: Magnesium (Mg) - Product: Formation of a Grignard reagent (indicated by the arrow leading to an open box). - Second Reaction: - Reaction with a carbonyl compound (ketone) - Two Step Process: (1) react with the Grignard reagent, (2) subsequent reaction shown leading to the final product with an OH group in the beta position. 2. **Second Synthesis**: - Starting Material: Para-bromoacetophenone (Bromine and Acetophenone group). - First Reaction: - Reagent: Magnesium (Mg) - Product: Formation of a Grignard reagent (indicated by the arrow leading to an open box). - Second Reaction: - Reaction with an aldehyde - Subsequent reaction showing further transformation to final products. 3. **Third Synthesis**: - Starting Material: Benzene ring with a Bromine and an alcohol (OH) group in alpha position. - First Reaction: - Reagent: unspecified carbonyl compound - Product: Formation of intermediate product. - Reagent sequence not fully specified (indicated by the numbered boxes 1) and 2) for steps) The synthesis diagrams depict several key organic transformations including the formation of Grignard reagents, nucleophilic additions to carbonyl groups, and subsequent rearrangements or substitutions leading to final alcohol products. **Note:** For each reaction step, further details about reagents, reaction conditions (like solvents, temperatures, catalysts, etc.), and purification steps would typically be needed to fully specify the synthetic route.
Transcribed Image Text:**Synthesis Problems for Educational Purposes** **Problem 6**: Complete the following syntheses by providing the reagents and conditions at the reaction arrows. (Multiple steps: 1) do this... 2) then do this, etc.) **Synthesis Pathways and Diagrams:** 1. **First Synthesis**: - Starting Material: Benzene ring with a Bromine (Br) substituent. - First Reaction: - Reagent: Magnesium (Mg) - Product: Formation of a Grignard reagent (indicated by the arrow leading to an open box). - Second Reaction: - Reaction with a carbonyl compound (ketone) - Two Step Process: (1) react with the Grignard reagent, (2) subsequent reaction shown leading to the final product with an OH group in the beta position. 2. **Second Synthesis**: - Starting Material: Para-bromoacetophenone (Bromine and Acetophenone group). - First Reaction: - Reagent: Magnesium (Mg) - Product: Formation of a Grignard reagent (indicated by the arrow leading to an open box). - Second Reaction: - Reaction with an aldehyde - Subsequent reaction showing further transformation to final products. 3. **Third Synthesis**: - Starting Material: Benzene ring with a Bromine and an alcohol (OH) group in alpha position. - First Reaction: - Reagent: unspecified carbonyl compound - Product: Formation of intermediate product. - Reagent sequence not fully specified (indicated by the numbered boxes 1) and 2) for steps) The synthesis diagrams depict several key organic transformations including the formation of Grignard reagents, nucleophilic additions to carbonyl groups, and subsequent rearrangements or substitutions leading to final alcohol products. **Note:** For each reaction step, further details about reagents, reaction conditions (like solvents, temperatures, catalysts, etc.), and purification steps would typically be needed to fully specify the synthetic route.
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