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Complete the following reaction and provide the detailed mechanism H*

Complete the following reaction and provide the detailed mechanism H*

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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**Transcription:** 1. Complete the following reaction and provide the detailed mechanism. **Reaction Scheme:** - Reactants: Cyclohexanone (a six-membered ring with a ketone group) and pyrrolidine (a five-membered ring with a secondary amine group). - Reaction Condition: Presence of an acid catalyst (H⁺). To solve this problem, consider the following: **Reaction Mechanism** - Identify the role of the acid catalyst (H⁺) in promoting the reaction between cyclohexanone and pyrrolidine. - Determine the nucleophilic attack of the amine on the carbonyl carbon of cyclohexanone. - Describe the formation of any intermediate species, such as an iminium ion. - Conclude with the final product that results from the completion of the reaction, such as a cyclohexane ring substituted with a pyrrolidine moiety. **Key Points to Address:** - Draw each step of the mechanism, highlighting the movement of electrons. - Explain any resonance structures if applicable. - Discuss any stereochemistry or regioselectivity considerations. This transcription guides students through understanding and solving a typical organic reaction involving nucleophilic attack on a carbonyl group.
Transcribed Image Text:**Transcription:** 1. Complete the following reaction and provide the detailed mechanism. **Reaction Scheme:** - Reactants: Cyclohexanone (a six-membered ring with a ketone group) and pyrrolidine (a five-membered ring with a secondary amine group). - Reaction Condition: Presence of an acid catalyst (H⁺). To solve this problem, consider the following: **Reaction Mechanism** - Identify the role of the acid catalyst (H⁺) in promoting the reaction between cyclohexanone and pyrrolidine. - Determine the nucleophilic attack of the amine on the carbonyl carbon of cyclohexanone. - Describe the formation of any intermediate species, such as an iminium ion. - Conclude with the final product that results from the completion of the reaction, such as a cyclohexane ring substituted with a pyrrolidine moiety. **Key Points to Address:** - Draw each step of the mechanism, highlighting the movement of electrons. - Explain any resonance structures if applicable. - Discuss any stereochemistry or regioselectivity considerations. This transcription guides students through understanding and solving a typical organic reaction involving nucleophilic attack on a carbonyl group.
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