Come up with a detailed mechanism for the following cyclization that also includes all resonance strictures for any intermediates that form. Also, explain why the alkyl bromide portion of the molecule remains intact in the product even though the reaction conditions are strongly basic/nucleophilic. Br Br NaOMe Me Me Me Me MeOH MeO2C 0 °C MeO₂C
Come up with a detailed mechanism for the following cyclization that also includes all resonance strictures for any intermediates that form. Also, explain why the alkyl bromide portion of the molecule remains intact in the product even though the reaction conditions are strongly basic/nucleophilic. Br Br NaOMe Me Me Me Me MeOH MeO2C 0 °C MeO₂C
Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter26: Aldol And Claisen Reactions
Section: Chapter Questions
Problem 26E
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