Co,H EtzN DBU CH;SO, phenylacetic acid CH;SO; rofecoxib

Q: Enalapril, a drug used to treat hypertension, is prepared from compounds D and E by reductive…

A:

Q: What product is obtained when ethylamine reacts with excess methyl iodide in a basic solution of…

A: Please find below the reaction with mechanism.

Q: Reaction of X and phenylacetic acid forms an intermediate Y, which undergoes an intramolecular…

A:

Q: Look at the imide, the nitrogen analog of an anhydride below: a) For a neutral imide, will the…

A: Imides are a class of organic compounds that contain a carbonyl group (C=O) attached to a nitrogen…

Q: The –NHCOR group of an amide is an activating group, but it is not as strongly activating as NH2.…

A: Given: The –NHCOR group of an amide is an activating group, but it is not as strongly activating as…

Q: 1. Write chemical equations for the preparation of the following compounds from either diethyl…

A: According to the Bartleby guidelines for the multipart questions I can solve only first three…

Q: Which combination(s) of amine and carbonyl compound c used to prepare the following product by…

A:

Q: Answer the following questions about benzphetamine, a habit-forming diet pill sold under the trade…

A: (a)

Q: Draw a stepwise mechanism for the conversion of lactone C to carboxylic acid  D. C is a key…

A:

Q: 'N' N. • HCI N. H3C`CH3

A: •Tripelennamine having various applications because it's metabolites show various properties…

Q: Draw the structure (including stereochemistry) of the cyclic hemiacetal(s) formed when each hydroxy…

A: Concept introduction: Hemiacetal are formed for the compound having both hydroxyl group and aldehyde…

Q: 1. Why is acetanilide no longer available as a drug in the market? 2. Why is the synthesis of…

A:

Q: Answer the following questions about atomoxetine, a drug used to treatattention deficit…

A: The amides that can be reduced to form atomoxetine are:  1. 2.

Q: 18.4 Characteristic Reactions of Anhydrides, Esters, and Amides 4 What product forms when ethyl…

A:

Q: Pivampicillin is a methylpivoxyl ester of ampicillin. It is prepared as a pro-drug to improve the…

A: Amphicillin is antibiotics used to treat for many infection . In ampicillin having carboxylic acid…

Q: 20.58 Fluphenazine is an antipsychotic drug that is administered as an ester prodrug via…

A:

Q: Quebrachamine is isolated from quebracho bark and it has adrenergic blocking activities for a…

A:

Q: β-Vetivone is isolated from vetiver, a perennial grass that yields a variety ofcompounds used in…

A: Michael addition: The Michael addition begins with the removal of a proton from an ?,?-unsaturated…

Q: What is the correct IUPAC name for the following molecule? N-ethyl-N-methyl-2-propyl cyclohexanamine…

A: IUPAC nomenclature of organic chemistry is a method of naming organic chemical compounds as…

Q: H,N NH COC,H; C. C,H5. 1. C,H,O¯N * 2. H,0 9. 2) \4. C=0 O + 2C,H;OH C,H, NH C,H; COC,H, H,N…

A:

Q: Identify A in the attached reaction sequence, and draw a mechanism forthe conversion of A to B. B…

A: The Sharpless asymmetric epoxidation involves the reaction of allylic alcohols with the titanium…

Q: The following three derivatives of succinimide are anticonvulsants that have found use in the…

A: The organic syntheses are very useful in the preparation of drugs which are useful in the treatment…

Q: Which of the following statements are true regarding the relative electrophilicity of acetic…

A: The given molecule is acetic anhydride. Draw the structure of this compound.

Q: What enolate is formed when each ketone is treated with LDA in THF solution? What enolate is formed…

A: LDA is a strong non nucleophilic base and it abstracts proton from alpha position of less hindered…

Q: Identify compounds A and B, two synthetic intermediates in the 1979 synthesis of the plant growth…

A: Gibberellic acid is a hormone found in plants and fungi. Its has a chemical formula as C19H22O6. It…

Q: 19.7 Hydrolysis of Acetals, Imines, and Enamines Identify the amine generated when the following…

A: Given,The reaction is:

Q: What starting materials are needed to prepare each drug using reductive amination? Give all possible…

A: a) Reductive amination is a two-venture strategy that changes over aldehydes and ketones into…

Q: Reaction of X and phenylacetic acid forms an intermediate Y, which undergoes an intramolecular…

A:

Q: 1) Draw AND name the product that would result upon treatment of R-3-methylheptanal with Excess…

A: We’ll answer the first question since the exact one wasn’t specified. Please submit a new question…

Q: Show how to synthesize the following amines from the indicated starting materials byreductive…

A: To synthesize N-Cyclohexylaniline from cyclohexanone   The primary amine can be synthesized from the…

Q: 1) How might you convert geraniol into either ethyl geranylacetate or geranylacetone? Geraniol CH₂OH…

A:

Q: WH₂ aniline позовно + CH3 CH 3 EYNH-C-CH3+CHз соон acetanilide

A: In a nucleophilic substitution reaction, the nucleophile attacks the electrophilic center. Then…

Q: Reductive amination requires a hydrogen on the carbonyl carbon to proceed BECAUSE Reductive…

A: Reductive amination reaction is a “carbonyl condensation reaction” is one in which two carbonyl‑…

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.