20.58 Fluphenazine is an antipsychotic drug that is administered as an ester prodrug via intramuscular injection: N. 'N CF3 Fluphenazine decanoate The hydrophobic tail of the ester is deliberately designed to enable a slow release of the prodrug into the bloodstream, where the prodrug is rapidly hydrolyzed to produce the active drug. (a) Draw the structure of the active drug. (b) Draw the structure of and assign a systematic name for the carbox- ylic acid that is produced as a by-product of the hydrolysis step.

20.58 Fluphenazine is an antipsychotic drug that is administered as an ester prodrug via intramuscular injection: N. 'N CF3 Fluphenazine decanoate The hydrophobic tail of the ester is deliberately designed to enable a slow release of the prodrug into the bloodstream, where the prodrug is rapidly hydrolyzed to produce the active drug. (a) Draw the structure of the active drug. (b) Draw the structure of and assign a systematic name for the carbox- ylic acid that is produced as a by-product of the hydrolysis step.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Concept explainers

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.

Question

20.58 Fluphenazine is an antipsychotic drug that is administered as
an ester prodrug via intramuscular injection:
CF3
Fluphenazine decanoate
The hydrophobic tail of the ester is deliberately designed to enable a slow
release of the prodrug into the bloodstream, where the prodrug is rapidly
hydrolyzed to produce the active drug.
(a) Draw the structure of the active drug.
(b) Draw the structure of and assign a systematic name for the carbox-
ylic acid that is produced as a by-product of the hydrolysis step.

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