CO2 Basement membrane Endothelium 2 CO2 + H₂O Carbonic anhydrase H₂CO3 H+ HCO3™ Plasma Systemic capillary Erythrocyte Hb CI- HCO3 CI Plasma Syst

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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### The Transport of Carbon Dioxide in Blood

**Diagram Explanation:**

The image illustrates the process of carbon dioxide (CO₂) transport in the blood, specifically within an erythrocyte (red blood cell) in the systemic capillary.

1. **Entry of CO₂:**
   - CO₂ from the systemic cells diffuses into the erythrocyte.
   - Label: CO₂

2. **Formation of Carbonic Acid:**
   - CO₂ combines with water (H₂O) inside the erythrocyte.
   - This reaction is catalyzed by the enzyme carbonic anhydrase.
   - The reaction produces carbonic acid (H₂CO₃), which further dissociates into hydrogen ions (H⁺) and bicarbonate ions (HCO₃⁻).
   - Labels: 
     - CO₂ + H₂O
     - H₂CO₃
     - H⁺
     - HCO₃⁻

3. **Chloride Shift:**
   - Bicarbonate ions (HCO₃⁻) are transported out of the erythrocyte into the plasma.
   - Chloride ions (Cl⁻) move into the erythrocyte to maintain ionic balance, a process known as the chloride shift.
   - Labels: 
     - HCO₃⁻ (moving out) 
     - Cl⁻ (moving in)

4. **Hemoglobin Buffering:**
   - Hemoglobin (Hb) within the erythrocyte binds to the hydrogen ions (H⁺), reducing acidity inside the cell and thus playing a crucial role in maintaining pH balance.
   - Label: Hb

**General Notes:**
- The systemic capillary is lined by the basement membrane and endothelium.
- The diagram also includes a close-up view showing systemic cells that release CO₂ as a byproduct of cellular metabolism.
- The plasma, a component of the blood, surrounds the erythrocyte and contains many dissolved substances, including gases, nutrients, and waste products.

Understanding this process is essential as it highlights the critical function of erythrocytes in transporting CO₂ from tissues to lungs for exhalation, and maintaining acid-base balance in the body.
Transcribed Image Text:### The Transport of Carbon Dioxide in Blood **Diagram Explanation:** The image illustrates the process of carbon dioxide (CO₂) transport in the blood, specifically within an erythrocyte (red blood cell) in the systemic capillary. 1. **Entry of CO₂:** - CO₂ from the systemic cells diffuses into the erythrocyte. - Label: CO₂ 2. **Formation of Carbonic Acid:** - CO₂ combines with water (H₂O) inside the erythrocyte. - This reaction is catalyzed by the enzyme carbonic anhydrase. - The reaction produces carbonic acid (H₂CO₃), which further dissociates into hydrogen ions (H⁺) and bicarbonate ions (HCO₃⁻). - Labels: - CO₂ + H₂O - H₂CO₃ - H⁺ - HCO₃⁻ 3. **Chloride Shift:** - Bicarbonate ions (HCO₃⁻) are transported out of the erythrocyte into the plasma. - Chloride ions (Cl⁻) move into the erythrocyte to maintain ionic balance, a process known as the chloride shift. - Labels: - HCO₃⁻ (moving out) - Cl⁻ (moving in) 4. **Hemoglobin Buffering:** - Hemoglobin (Hb) within the erythrocyte binds to the hydrogen ions (H⁺), reducing acidity inside the cell and thus playing a crucial role in maintaining pH balance. - Label: Hb **General Notes:** - The systemic capillary is lined by the basement membrane and endothelium. - The diagram also includes a close-up view showing systemic cells that release CO₂ as a byproduct of cellular metabolism. - The plasma, a component of the blood, surrounds the erythrocyte and contains many dissolved substances, including gases, nutrients, and waste products. Understanding this process is essential as it highlights the critical function of erythrocytes in transporting CO₂ from tissues to lungs for exhalation, and maintaining acid-base balance in the body.
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