CH₂OH OH OPO3-2 OH

Human Anatomy & Physiology (11th Edition)
11th Edition
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Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Will the amount of glycogen be higher or lower than normal or unchanged?

  1. Pyridoxal phosphate is covalently bonded to glycogen phosphorylase via a Schiff base to Lys 680. What effect would the mutation of Lys680Ala have on the breakdown of glycogen?(This notation means the following: K680 is the normal amino acid in this enzyme.  It has been mutated to 680A.) 
  2. Loss of the gene for the kinase that phosphorylates GSK3 on glycogen synthesis.
  3. Effect of the substrate analog below on glycogen synthesis.

 

The image depicts the chemical structure of a cyclic sugar phosphate, specifically a sugar monophosphate. The structure is a ring composed of carbon atoms and one oxygen atom, forming a pyranose ring.

### Detailed Description:

- **Ring Structure**: The ring contains five carbon atoms and one oxygen atom. The oxygen is part of the ring, indicating it is a hexose sugar (six carbons, five in the ring, and one attached).

- **Hydroxy (OH) Groups**:
  - There are hydroxy groups (OH) attached to three of the carbon atoms in the ring. These groups are involved in various biological reactions and often contribute to the compound’s solubility in water.
  - One hydroxy group is on the first carbon atom in the ring (left side).
  - Another hydroxy group is on the second carbon atom in the ring (bottom right).
  - An additional hydroxy group is present outside the ring on the fifth carbon atom (top of the ring), which is connected to the “CH₂OH” group.

- **CH₂OH Group**: 
  - The “CH₂OH” group is attached to the carbon atom outside the pyranose ring, indicating the sugar is not just a simple ring but part of a larger structure.

- **Phosphate Group (OPO₃²⁻)**:
  - A phosphate group is attached to the third carbon of the ring (bottom), indicated by the "OPO₃²⁻" notation.
  - This group has a net negative charge of -2, which is typical for phosphate groups as they are often ionized at physiological pH.

This structure is typical of sugar monophosphates, which are important intermediates in metabolism, being involved in pathways like glycolysis and nucleotide synthesis. The presence of the phosphate group suggests the molecule could be involved in energy transfer or signaling within the cell.
Transcribed Image Text:The image depicts the chemical structure of a cyclic sugar phosphate, specifically a sugar monophosphate. The structure is a ring composed of carbon atoms and one oxygen atom, forming a pyranose ring. ### Detailed Description: - **Ring Structure**: The ring contains five carbon atoms and one oxygen atom. The oxygen is part of the ring, indicating it is a hexose sugar (six carbons, five in the ring, and one attached). - **Hydroxy (OH) Groups**: - There are hydroxy groups (OH) attached to three of the carbon atoms in the ring. These groups are involved in various biological reactions and often contribute to the compound’s solubility in water. - One hydroxy group is on the first carbon atom in the ring (left side). - Another hydroxy group is on the second carbon atom in the ring (bottom right). - An additional hydroxy group is present outside the ring on the fifth carbon atom (top of the ring), which is connected to the “CH₂OH” group. - **CH₂OH Group**: - The “CH₂OH” group is attached to the carbon atom outside the pyranose ring, indicating the sugar is not just a simple ring but part of a larger structure. - **Phosphate Group (OPO₃²⁻)**: - A phosphate group is attached to the third carbon of the ring (bottom), indicated by the "OPO₃²⁻" notation. - This group has a net negative charge of -2, which is typical for phosphate groups as they are often ionized at physiological pH. This structure is typical of sugar monophosphates, which are important intermediates in metabolism, being involved in pathways like glycolysis and nucleotide synthesis. The presence of the phosphate group suggests the molecule could be involved in energy transfer or signaling within the cell.
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