In the design of H2 antagonist, the polar guanidine group was proposed to interact with the antagonist binding region by two hydrogen bonds. Compound A is designed based on modification of compound B and has higher antagonist activity compared to compound B. H2N NH NH2 NH HN Guanidine Guanidine HN What drug design strategy has been used here? O Rigidification O Simplification O Substituent variation O Chain Extension

In the design of H2 antagonist, the polar guanidine group was proposed to interact with the antagonist binding region by two hydrogen bonds. Compound A is designed based on modification of compound B and has higher antagonist activity compared to compound B. H2N NH NH2 NH HN Guanidine Guanidine HN What drug design strategy has been used here? O Rigidification O Simplification O Substituent variation O Chain Extension

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

In the design of H2 antagonist, the polar guanidine group was proposed to interact with the
antagonist binding region by two hydrogen bonds. Compound A is designed based on modification
of compound B and has higher antagonist activity compared to compound B.
H2N
NH
NH2
NH
HN
Guanidine
Guanidine
HN
What drug design strategy has been used here?
O Rigidification
O Simplification
O Substituent variation
O Chain Extension

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