In the design of H2 antagonist, the polar guanidine group was proposed to interact with the antagonist binding region by two hydrogen bonds. Compound A is designed based on modification of compound B and has higher antagonist activity compared to compound B. H2N NH NH2 NH HN Guanidine Guanidine HN What drug design strategy has been used here? O Rigidification O Simplification O Substituent variation O Chain Extension
In the design of H2 antagonist, the polar guanidine group was proposed to interact with the antagonist binding region by two hydrogen bonds. Compound A is designed based on modification of compound B and has higher antagonist activity compared to compound B. H2N NH NH2 NH HN Guanidine Guanidine HN What drug design strategy has been used here? O Rigidification O Simplification O Substituent variation O Chain Extension
Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions
Section21.SE: Something Extra
Problem 30VC
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![In the design of H2 antagonist, the polar guanidine group was proposed to interact with the
antagonist binding region by two hydrogen bonds. Compound A is designed based on modification
of compound B and has higher antagonist activity compared to compound B.
H2N
NH
NH2
NH
HN
Guanidine
Guanidine
HN
What drug design strategy has been used here?
O Rigidification
O Simplification
O Substituent variation
O Chain Extension](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F4856819d-8244-4382-b245-2ec1dff9e68b%2Fd861cd76-baa9-4c2c-ae08-10985fbbf9a5%2Fx23clpa_processed.png&w=3840&q=75)
Transcribed Image Text:In the design of H2 antagonist, the polar guanidine group was proposed to interact with the
antagonist binding region by two hydrogen bonds. Compound A is designed based on modification
of compound B and has higher antagonist activity compared to compound B.
H2N
NH
NH2
NH
HN
Guanidine
Guanidine
HN
What drug design strategy has been used here?
O Rigidification
O Simplification
O Substituent variation
O Chain Extension
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