**Task 2: Transformation Process Using Williamson Ether Synthesis** **Objective:** Show how to carry out the following chemical transformation: **Starting Material:** - A brominated compound: \[ \begin{array}{c} \text{Br} \\ | \\ \text{CH}_3\text{-C-CH}_2\text{-CH}_2\text{-} \end{array} \] **Product:** - A methoxy amine compound: \[ \begin{array}{c} \text{CH}_3\text{-C-CH}_2\text{-CH}_2\text{-OMe} \\ \quad \quad \quad \quad \quad \quad \quad \quad | \\ \quad \quad \quad \quad \quad \quad \quad \quad \text{N} \\ \quad \quad \quad \quad \quad \quad \quad \quad | \\ \quad \quad \quad \quad \quad \quad \quad \quad \text{CH}_3 \end{array} \] **Instructions:** - **Show all required reagents and the product after each step.** - **You do not have to use curved arrows.** **Important Notes:** - **Automatic zero points** if any of the following are not adhered to: - You must use the **Williamson ether synthesis**. - You are not allowed to use any reactions we haven’t yet covered. **Guidelines for the Transformation:** 1. **Step 1:** Outline the required reagents needed for the transformation. 2. **Step 2:** Show the intermediate and final product, emphasizing the formation of the ether linkage. 3. **Attention to Detail:** Ensure all chemical structures are correctly presented. **Key Considerations:** - Consider nucleophilic substitution (typically SN2) in Williamson ether synthesis. - Note that bromine (Br) is the leaving group in the initial step. By following these instructions, you will successfully demonstrate the transformation from the given brominated compound to the methoxy amine product using the appropriate organic synthesis techniques.
Reactive Intermediates
In chemistry, reactive intermediates are termed as short-lived, highly reactive atoms with high energy. They rapidly transform into stable particles during a chemical reaction. In specific cases, by means of matrix isolation and at low-temperature reactive intermediates can be isolated.
Hydride Shift
A hydride shift is a rearrangement of a hydrogen atom in a carbocation that occurs to make the molecule more stable. In organic chemistry, rearrangement of the carbocation is very easily seen. This rearrangement can be because of the movement of a carbocation to attain stability in the compound. Such structural reorganization movement is called a shift within molecules. After the shifting of carbocation over the different carbon then they form structural isomers of the previous existing molecule.
Vinylic Carbocation
A carbocation where the positive charge is on the alkene carbon is known as the vinyl carbocation or vinyl cation. The empirical formula for vinyl cation is C2H3+. In the vinyl carbocation, the positive charge is on the carbon atom with the double bond therefore it is sp hybridized. It is known to be a part of various reactions, for example, electrophilic addition of alkynes and solvolysis as well. It plays the role of a reactive intermediate in these reactions.
Cycloheptatrienyl Cation
It is an aromatic carbocation having a general formula, [C7 H7]+. It is also known as the aromatic tropylium ion. Its name is derived from the molecule tropine, which is a seven membered carbon atom ring. Cycloheptatriene or tropylidene was first synthesized from tropine.
Stability of Vinyl Carbocation
Carbocations are positively charged carbon atoms. It is also known as a carbonium ion.
![**Task 2: Transformation Process Using Williamson Ether Synthesis**
**Objective:**
Show how to carry out the following chemical transformation:
**Starting Material:**
- A brominated compound:
\[
\begin{array}{c}
\text{Br} \\
| \\
\text{CH}_3\text{-C-CH}_2\text{-CH}_2\text{-}
\end{array}
\]
**Product:**
- A methoxy amine compound:
\[
\begin{array}{c}
\text{CH}_3\text{-C-CH}_2\text{-CH}_2\text{-OMe} \\
\quad \quad \quad \quad \quad \quad \quad \quad | \\
\quad \quad \quad \quad \quad \quad \quad \quad \text{N} \\
\quad \quad \quad \quad \quad \quad \quad \quad | \\
\quad \quad \quad \quad \quad \quad \quad \quad \text{CH}_3
\end{array}
\]
**Instructions:**
- **Show all required reagents and the product after each step.**
- **You do not have to use curved arrows.**
**Important Notes:**
- **Automatic zero points** if any of the following are not adhered to:
- You must use the **Williamson ether synthesis**.
- You are not allowed to use any reactions we haven’t yet covered.
**Guidelines for the Transformation:**
1. **Step 1:** Outline the required reagents needed for the transformation.
2. **Step 2:** Show the intermediate and final product, emphasizing the formation of the ether linkage.
3. **Attention to Detail:** Ensure all chemical structures are correctly presented.
**Key Considerations:**
- Consider nucleophilic substitution (typically SN2) in Williamson ether synthesis.
- Note that bromine (Br) is the leaving group in the initial step.
By following these instructions, you will successfully demonstrate the transformation from the given brominated compound to the methoxy amine product using the appropriate organic synthesis techniques.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F21b4e0fd-2deb-4010-bcaa-5e17a99ed39c%2Fb8eaad6a-8af0-4ccd-8383-9d1b9723932c%2F7uk490i_processed.png&w=3840&q=75)
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