catalytic H* CH;ČOH + CH;OH CH;COCH3 + H2O The reaction shown above is an acid-catalyzed Fischer esterification with excess methanol. Thinking about the mechanism for this reaction, place the intermediates shown below in the CORRECT order that they occur during the mechanism. One or more of the intermediates may be wrong or not needed, so choose carefully! Enter your answer like this- 2,1,5,4 –if you think that is the correct order. ORDER = [order] OH OH CH3CH2OH HOCH3 *OH CH;COH CH;CH2OH ÓCH3 CH;Č=0 1 2 3 4 OH он CH3C-ÓH2 CH3COCH3 CH3Č-OH2 CH3C-OCH3 H OCH3 6 7 8

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Designing a Synthesis

Organic synthesis is a branch of chemical synthesis that involves the planned construction of organic compounds/molecules from smaller units that possess functional groups. Friedrich Wöhler was the first scientist who designed the synthesis of an organic compound, urea from inorganic starting materials silver cyanate with ammonium chloride via a simple, one-step synthesis.