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Can I get help on how to do a concept map to the introduction of the Welch-Reardon, et al article provided below in the image. It can either be a drawing or a ppt slide. A requirement would be to utilize connecting words and identify the background of the article. Also, to research the problem and questions.

Can I get help on how to do a concept map to the introduction of the Welch-Reardon, et al article provided below in the image. It can either be a drawing or a ppt slide. A requirement would be to utilize connecting words and identify the background of the article. Also, to research the problem and questions.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Can I get help on how to do a concept map to the introduction of the Welch-Reardon, et al article provided below in the image. It can either be a drawing or a ppt slide. A requirement would be to utilize connecting words and identify the background of the article. Also, to research the problem and questions. 

**Introduction** Angiogenesis is a multi-step, tightly regulated process that plays a crucial role during embryogenesis and wound healing, as well as in pathological conditions such as tumor growth (Conway et al., 2001; Folkman, 1985; Risau, 1997). During sprouting angiogenesis, endothelial cells (EC) are activated in response to angiogenic stimuli, the best characterized of which is vascular endothelial growth factor (VEGF) (Carmeliet, 2000; Conway et al., 2001). EC activation triggers a cascade of events, including degradation of the adjacent basement membrane, migration of nascent sprouts into the surrounding extracellular matrix (ECM). --- **Affiliations:** 1. The Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA. 2. The Department of Chemical Engineering and Materials Science, University of California Irvine, Irvine, CA 92697, USA. 3. The Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA 92697, USA. 4. The Department of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA. 5. The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California Irvine, Irvine, CA 92697, USA. *Author for correspondence: cchughes@uci.edu* **Received 26 September 2013; Accepted 26 January 2014**
Transcribed Image Text:**Introduction** Angiogenesis is a multi-step, tightly regulated process that plays a crucial role during embryogenesis and wound healing, as well as in pathological conditions such as tumor growth (Conway et al., 2001; Folkman, 1985; Risau, 1997). During sprouting angiogenesis, endothelial cells (EC) are activated in response to angiogenic stimuli, the best characterized of which is vascular endothelial growth factor (VEGF) (Carmeliet, 2000; Conway et al., 2001). EC activation triggers a cascade of events, including degradation of the adjacent basement membrane, migration of nascent sprouts into the surrounding extracellular matrix (ECM). --- **Affiliations:** 1. The Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA. 2. The Department of Chemical Engineering and Materials Science, University of California Irvine, Irvine, CA 92697, USA. 3. The Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA 92697, USA. 4. The Department of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA. 5. The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California Irvine, Irvine, CA 92697, USA. *Author for correspondence: cchughes@uci.edu* **Received 26 September 2013; Accepted 26 January 2014**
Transcription for Educational Website: --- The formation of lumens, branching, anastomosis, and a return to quiescence occurs once support cells have been recruited to the newly formed vessel (Carmeliet, 2000; Conway et al., 2001; Risau, 1997). Initiation of sprouting requires the generation of at least two distinct EC phenotypes—tip cells and trunk cells. Each assumes a different morphology and performs unique functions. A tip cell leads the sprout; it is polarized along its anterior-posterior axis, rarely proliferates, and is highly migratory (del Toro et al., 2010; Hellström et al., 2007; Jakobsson et al., 2010; Sainson et al., 2008). Trunk cells trail tip cells; they are proliferative, apically-basally polarized, and form the vessel lumen (Ribatti and Crivellato, 2012). Gene expression profiles reveal tip cells to be highly enriched in VEGF receptor 2 (VEGFR2) (Gerhardt et al., 2003; Jakobsson et al., 2010; Ribatti and Crivellato, 2012; Sainson et al., 2008), platelet-derived growth factor B (PDGFB) (Ribatti and Crivellato, 2012; Sainson et al., 2008), neuropilin receptor 2 (NRP2) (Sainson et al., 2008), Jagged 1 (Jag1) (Johnston et al., 2009; Sainson et al., 2008), and membrane type 1 matrix metalloproteinase (MT1-MMP) (van Hinsbergh and Koolwijk, 2008; Yana et al., 2007), and delta-like 4 (Dll4) (Hellström et al., 2007; Suchting et al., 2007). Expression of tip cell genes and induction of angiogenic sprouting are stimulated and regulated by pro-angiogenic cytokines including VEGF (Conway et al., 2001; Ribatti and Crivellato, 2012), tumor necrosis factor α (TNFα) (Otrook et al., 2007; Sainson et al., 2008), transforming growth factor β (TGFβ) (
Transcribed Image Text:Transcription for Educational Website: --- The formation of lumens, branching, anastomosis, and a return to quiescence occurs once support cells have been recruited to the newly formed vessel (Carmeliet, 2000; Conway et al., 2001; Risau, 1997). Initiation of sprouting requires the generation of at least two distinct EC phenotypes—tip cells and trunk cells. Each assumes a different morphology and performs unique functions. A tip cell leads the sprout; it is polarized along its anterior-posterior axis, rarely proliferates, and is highly migratory (del Toro et al., 2010; Hellström et al., 2007; Jakobsson et al., 2010; Sainson et al., 2008). Trunk cells trail tip cells; they are proliferative, apically-basally polarized, and form the vessel lumen (Ribatti and Crivellato, 2012). Gene expression profiles reveal tip cells to be highly enriched in VEGF receptor 2 (VEGFR2) (Gerhardt et al., 2003; Jakobsson et al., 2010; Ribatti and Crivellato, 2012; Sainson et al., 2008), platelet-derived growth factor B (PDGFB) (Ribatti and Crivellato, 2012; Sainson et al., 2008), neuropilin receptor 2 (NRP2) (Sainson et al., 2008), Jagged 1 (Jag1) (Johnston et al., 2009; Sainson et al., 2008), and membrane type 1 matrix metalloproteinase (MT1-MMP) (van Hinsbergh and Koolwijk, 2008; Yana et al., 2007), and delta-like 4 (Dll4) (Hellström et al., 2007; Suchting et al., 2007). Expression of tip cell genes and induction of angiogenic sprouting are stimulated and regulated by pro-angiogenic cytokines including VEGF (Conway et al., 2001; Ribatti and Crivellato, 2012), tumor necrosis factor α (TNFα) (Otrook et al., 2007; Sainson et al., 2008), transforming growth factor β (TGFβ) (
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The use of molecular biology methods is critical. It can also aid in the synthesis of target proteins, which can revolutionize enzymatic and harmonic applications in biotechnology. To overcome research difficulties, researchers use several molecular biology approaches. Molecular biology aids in the isolation, extraction, and modification of the new clone, among other things.

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