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(c) ADP binds to platelets to initiate the activation process. Two binding receptors were identified on platelets, one with a Kp of 0.35 μM (receptor A) and one with a KD pf 7.9 µM (receptor B). Which receptor is a low-affinity binding site and which site is a high-affinity binding site? (d) The ADP concentration required to activate a platelet is in the range of 0.1-0.5 μM. Which receptor will be more effective at activating the platelet? Explain your answer.

(c) ADP binds to platelets to initiate the activation process. Two binding receptors were identified on platelets, one with a Kp of 0.35 μM (receptor A) and one with a KD pf 7.9 µM (receptor B). Which receptor is a low-affinity binding site and which site is a high-affinity binding site? (d) The ADP concentration required to activate a platelet is in the range of 0.1-0.5 μM. Which receptor will be more effective at activating the platelet? Explain your answer.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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(c) ADP binds to platelets to initiate the activation process. Two binding receptors were identified on platelets, one with a Kp of 0.35 µM (receptor A) and one with a KD pf 7.9 µM (receptor B). Which receptor is a low-affinity binding site and which site is a high-affinity binding site? (d) The ADP concentration required to activate a platelet is in the range of 0.1-0.5 µM. Which receptor will be more effective at activating the platelet? Explain your answer.
Transcribed Image Text:(c) ADP binds to platelets to initiate the activation process. Two binding receptors were identified on platelets, one with a Kp of 0.35 µM (receptor A) and one with a KD pf 7.9 µM (receptor B). Which receptor is a low-affinity binding site and which site is a high-affinity binding site? (d) The ADP concentration required to activate a platelet is in the range of 0.1-0.5 µM. Which receptor will be more effective at activating the platelet? Explain your answer.
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