Bupropion, the hydrochloride of which was first marketed in 1985 by Burroughs Wellcome, now GlaxoSmithKline, is an antidepressant sold under the trade name Wellbutrin. During clinical trials, it was discovered that smokers, after one to two weeks on the drug, reported that their craving for tobacco lessened. Further clinical tri- als confirmed this finding, and the drug was marketed in 1997 under the trade name Zyban as an aid in smoking cessation. H Cl Br CI Bupropion
Carbohydrates
Carbohydrates are the organic compounds that are obtained in foods and living matters in the shape of sugars, cellulose, and starch. The general formula of carbohydrates is Cn(H2O)2. The ratio of H and O present in carbohydrates is identical to water.
Starch
Starch is a polysaccharide carbohydrate that belongs to the category of polysaccharide carbohydrates.
Mutarotation
The rotation of a particular structure of the chiral compound because of the epimerization is called mutarotation. It is the repercussion of the ring chain tautomerism. In terms of glucose, this can be defined as the modification in the equilibrium of the α- and β- glucose anomers upon its dissolution in the solvent water. This process is usually seen in the chemistry of carbohydrates.
L Sugar
A chemical compound that is represented with a molecular formula C6H12O6 is called L-(-) sugar. At the carbon’s 5th position, the hydroxyl group is placed to the compound’s left and therefore the sugar is represented as L(-)-sugar. It is capable of rotating the polarized light’s plane in the direction anticlockwise. L isomers are one of the 2 isomers formed by the configurational stereochemistry of the carbohydrates.
Is bupropion chiral? If so, how many of the possible stereoisomers are formed in this synthesis?
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