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Briefly describe the overall message of figure 1C

Briefly describe the overall message of figure 1C

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Briefly describe the overall message of figure 1C
(See figure on previous page) Fig. 1 Differentially expressed (DE) genes in the host. a Box plot of six genes that are a part of the gastrointestinal cancer pathway (one of the key disease pathways influenced by DE gene at q value <0.05 cutoff), showing differential expression between healthy and CF samples. b Disease and functional pathways that are most significantly enriched with DE genes (q value <0.05), sorted by the p value (cut off - log10(p value) < 5). The dark gray bars represent cancer-related pathways. c Gastrointestinal cancer pathway gene network with upregulated genes represented in green and downregulated genes represented in red. The intensity of the color is indicative of higher (brighter) or lower (duller) difference in expression. The shapes represent each protein's role (see legend) and the figure also illustrates the part of the cell they are most active in
Transcribed Image Text:(See figure on previous page) Fig. 1 Differentially expressed (DE) genes in the host. a Box plot of six genes that are a part of the gastrointestinal cancer pathway (one of the key disease pathways influenced by DE gene at q value <0.05 cutoff), showing differential expression between healthy and CF samples. b Disease and functional pathways that are most significantly enriched with DE genes (q value <0.05), sorted by the p value (cut off - log10(p value) < 5). The dark gray bars represent cancer-related pathways. c Gastrointestinal cancer pathway gene network with upregulated genes represented in green and downregulated genes represented in red. The intensity of the color is indicative of higher (brighter) or lower (duller) difference in expression. The shapes represent each protein's role (see legend) and the figure also illustrates the part of the cell they are most active in
20microbiome%20and%20CF%20host%20genes % 20% 20 (2).pdf gene regulation in cys... 7/15 - 100% +] B Normalized Count Disease and Function 100. 80000. 60000. 40000. 20000. CLCA4 2000. 0 Healthy CF Cell death of osteosarcoma cells. Processing of rRNA Solid tumor Cancer Translation Translation of protein Processing of RNA Malignant solid tumor Non hematologicmalignant neoplasm Synthesis of protein 1500. 1000. 500. TBX10 15000 10000. 5000. LCN2 0. Healthy CF Healthy CF -log10(P Value) C 0 5 10 15 20 Extracellular Space plasminogen activator NADPH oxidase SERPINE1 Other C16orf87 LDL Plasma Membrane Expression of protein Metabolism of protein Translation of RNA AS3MT JOSD1 Translation of mRNA DUB Non-melanoma solid tumor Tumorigenesis of tissue Expression of mRNA Cell death Neoplasia of epithelial tissue Necrosis Abdominal neoplasm Carcinoma SH3KBP1 NM61 UCHL5 PUBQLN4 Cytoplasm a SMYD5 CAPN2 RNF219 RB1CC1 EPDR1 DNMTY Adenocarcinoma TRIM27 Nath Splicing of RNA Abdominal cancer CHD4 NOOR1 ANAPC7 Metabolism of DNA E2F1 DNA replication Cell death of cancer cells Cell death of tumor cells USP31 Histone h4 CCNE1 Complex MED1 ---CCND2 TASPI Enzyme ACTL6A TP53INP1 YRDC Kinase ZBTB9 Group/Complex Necrosis of tumor Diamond-Blackfan anemia Targeting of protein Viral Infection Cell death of connective tissue cells Cell death of tumor cell lines Cell death of fibroblast cell lines. Aciduria Stabilization of protein Digestive organ tumor Fig. 1 (See legend on next page.) Nucleous Peptidase Transcription Regulator Other
Transcribed Image Text:20microbiome%20and%20CF%20host%20genes % 20% 20 (2).pdf gene regulation in cys... 7/15 - 100% +] B Normalized Count Disease and Function 100. 80000. 60000. 40000. 20000. CLCA4 2000. 0 Healthy CF Cell death of osteosarcoma cells. Processing of rRNA Solid tumor Cancer Translation Translation of protein Processing of RNA Malignant solid tumor Non hematologicmalignant neoplasm Synthesis of protein 1500. 1000. 500. TBX10 15000 10000. 5000. LCN2 0. Healthy CF Healthy CF -log10(P Value) C 0 5 10 15 20 Extracellular Space plasminogen activator NADPH oxidase SERPINE1 Other C16orf87 LDL Plasma Membrane Expression of protein Metabolism of protein Translation of RNA AS3MT JOSD1 Translation of mRNA DUB Non-melanoma solid tumor Tumorigenesis of tissue Expression of mRNA Cell death Neoplasia of epithelial tissue Necrosis Abdominal neoplasm Carcinoma SH3KBP1 NM61 UCHL5 PUBQLN4 Cytoplasm a SMYD5 CAPN2 RNF219 RB1CC1 EPDR1 DNMTY Adenocarcinoma TRIM27 Nath Splicing of RNA Abdominal cancer CHD4 NOOR1 ANAPC7 Metabolism of DNA E2F1 DNA replication Cell death of cancer cells Cell death of tumor cells USP31 Histone h4 CCNE1 Complex MED1 ---CCND2 TASPI Enzyme ACTL6A TP53INP1 YRDC Kinase ZBTB9 Group/Complex Necrosis of tumor Diamond-Blackfan anemia Targeting of protein Viral Infection Cell death of connective tissue cells Cell death of tumor cell lines Cell death of fibroblast cell lines. Aciduria Stabilization of protein Digestive organ tumor Fig. 1 (See legend on next page.) Nucleous Peptidase Transcription Regulator Other
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