Br CO,H Et,N DBU CH;SO, х phenylacetic acid CH;SO2 rofecoxib

Q: What 1° amine and carbonyl compound are needed to prepare each imine?

A: a.  The given compound is, 1° amine and carbonyl compound are needed to prepare the above compound…

Q: Reaction of X and phenylacetic acid forms an intermediate Y, which undergoes an intramolecular…

A:

Q: Propose a synthesis of the tranquilizer valnoctamide from diethyl malonate.

A: Synthesis of tranquilizer valnoctamide: In this synthesis, the first step involves diethyl malonate…

Q: pan Draw the structure(s) indicated by the curved-arrow me

A: Nucleophile O- abstract H+ from the other molecule.

Q: 1. Rank the following nitrogens or amines in order of decreasing basicity (strongest to weakest,…

A: In case of basicity only to check the availability of loan pair of electron on nitrogen atom when…

Q: The following intermediate was needed for the synthesis of tamoxifen, a widely used antiestrogen…

A:

Q: 18.4 Characteristic Reactions of Anhydrides, Esters, and Amides 4 What product forms when ethyl…

A:

Q: 20.58 Fluphenazine is an antipsychotic drug that is administered as an ester prodrug via…

A:

Q: Draw a structural formula for each amine and amine derivative. (a) N,N-Dimethylaniline (b)…

A: As per our guidelines we can only solve first three sub-parts of a question. Please resubmit other…

Q: What is the product when ethylbbenzoate is treated with excess ethanamine?

A:

Q: 17.56 What amides will form each amine on treatment with LIAIH4? a. oro 040 b. C.

A: Information of question

Q: Look at the imide, the nitrogen analog of an anhydride below: a) For a neutral imide, will the…

A: Substances that are electron deficient and tend to attack an electron-rich center are identified as…

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.