You are studying a biochemical pathway that requires ATP as an energy source. To your dismay, the reactions soon stop, partly because the ATP is rapidly used up and partly because an excess of ADP builds up and inhibits the enzymes involved. You are about to give up when the following table from a biochemistry textbook catches your eye. **Table of Reactions and Enzymes:** | Substrates | Enzymes | Products | ΔG° (kJ/mol) | |------------------------|---------|---------------------------|--------------| | Creatine + ATP | Enzyme A| Creatine-phosphate + ADP | -7.3 | | Pyrophosphate + H2O | Enzyme B| 2 Phosphate + H2O | -7.0 | | Glucose-6-phosphate + H2O | Enzyme C | Glucose + Phosphate | -3.3 | ΔG° indicates the standard free energy change, with negative values suggesting spontaneous reactions. **Question:** Which of the following reagents is/are most likely to revitalize your reaction? A. A vast excess of ATP B. Glucose 6-phosphate and enzyme D C. Creatine phosphate and enzyme A D. Pyrophosphate **Considerations:** - Increasing ATP can drive reactions forward by providing the necessary energy. - Other substrates and products might interact differently with the enzymes, potentially affecting pathway regulation.
You are studying a biochemical pathway that requires ATP as an energy source. To your dismay, the reactions soon stop, partly because the ATP is rapidly used up and partly because an excess of ADP builds up and inhibits the enzymes involved. You are about to give up when the following table from a biochemistry textbook catches your eye. **Table of Reactions and Enzymes:** | Substrates | Enzymes | Products | ΔG° (kJ/mol) | |------------------------|---------|---------------------------|--------------| | Creatine + ATP | Enzyme A| Creatine-phosphate + ADP | -7.3 | | Pyrophosphate + H2O | Enzyme B| 2 Phosphate + H2O | -7.0 | | Glucose-6-phosphate + H2O | Enzyme C | Glucose + Phosphate | -3.3 | ΔG° indicates the standard free energy change, with negative values suggesting spontaneous reactions. **Question:** Which of the following reagents is/are most likely to revitalize your reaction? A. A vast excess of ATP B. Glucose 6-phosphate and enzyme D C. Creatine phosphate and enzyme A D. Pyrophosphate **Considerations:** - Increasing ATP can drive reactions forward by providing the necessary energy. - Other substrates and products might interact differently with the enzymes, potentially affecting pathway regulation.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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