Below are data from a case-control study about the risk of stroke related to the "exposure" of smoking. Cases included individuals who were hospitalized at an Atlanta hospital for stroke. Controls consisted of individuals at the same hospital for reasons not related to strokes. Smoking History Yes No Total Stroke Case 381 119 500 No Stroke Controls 610 890 1,500 Total 991 1,009 2,000 7. Estimate the odds ratio of having a stroke (or becoming a case) comparing those with and without a smoking history. Describe in words what this means.

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Below are data from a case-control study about the risk of stroke related to the "exposure" of smoking. Cases included individuals who were hospitalized at an Atlanta hospital for stroke. Controls consisted of individuals at the same hospital for reasons not related to strokes.

| Smoking History | Stroke Case | No Stroke Controls | Total |
|------------------|-------------|---------------------|-------|
| Yes              | 381         | 610                 | 991   |
| No               | 119         | 890                 | 1,009 |
| Total            | 500         | 1,500               | 2,000 |

**7a.** Estimate the odds ratio of having a stroke (or becoming a case) comparing those with and without a smoking history. **Describe** in words what this means.

**7b.** If this was instead a cohort study and we were to calculate the risk ratio for this study, estimate the risk ratio (or relative risk) of having a stroke. **Describe** in words what this means.

**7c.** Is the **relative risk** of stroke for those with a smoking history (exposure +) versus those without a smoking history (exposure -) likely to be larger or smaller than the **odds ratio**? Why or why not.

**7d.** Assuming that strokes occur in less than 10% of the population, would you expect the difference between the two measures of risk (RR and OR) to be large? Why or why not. (Hint: Refer to lecture on "Measures of Disease Association")
Transcribed Image Text:Below are data from a case-control study about the risk of stroke related to the "exposure" of smoking. Cases included individuals who were hospitalized at an Atlanta hospital for stroke. Controls consisted of individuals at the same hospital for reasons not related to strokes. | Smoking History | Stroke Case | No Stroke Controls | Total | |------------------|-------------|---------------------|-------| | Yes | 381 | 610 | 991 | | No | 119 | 890 | 1,009 | | Total | 500 | 1,500 | 2,000 | **7a.** Estimate the odds ratio of having a stroke (or becoming a case) comparing those with and without a smoking history. **Describe** in words what this means. **7b.** If this was instead a cohort study and we were to calculate the risk ratio for this study, estimate the risk ratio (or relative risk) of having a stroke. **Describe** in words what this means. **7c.** Is the **relative risk** of stroke for those with a smoking history (exposure +) versus those without a smoking history (exposure -) likely to be larger or smaller than the **odds ratio**? Why or why not. **7d.** Assuming that strokes occur in less than 10% of the population, would you expect the difference between the two measures of risk (RR and OR) to be large? Why or why not. (Hint: Refer to lecture on "Measures of Disease Association")
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