Background: Margaret, a 35-year-old woman, who has history of hyperuricemia and gouty arthritis experienced progressive shortness of breath for a week. Limited movement has been complained by the patient because of her multiple painful swelling in her hands and elbows. She has also mentioned new lesions in his ear lobes. The patient is a former smoker with 10 pack year history and worked as a field laborer. Doctor’s Diagnosis: Gouty arthritis Nutrition: Usual Dietary Intake: 24-hr recall: Breakfast: Chickpea and legume salad, 1 cup non-fat milk Snack: Bean sprouts, poached eggs, nut parfait Lunch: Fried chicken sandwich from McDonald’s, French fries, 32-oz iced tea Late afternoon: 2 c chips, 1 beer Dinner: 1 breast, fried Fried Chicken, 1½ c potato salad, ¼ c green bean casserole, ½ c fruit salad, 1 c baked beans, iced tea 4. One treatment for hyperuricemia is administration of xanthine oxidase inhibitors like allopurinol. What is the biochemical rationale for this treatment? Discuss the mechanism and show an illustration how this drug able to alleviate symptoms of hyperuricemia?
Background: Margaret, a 35-year-old woman, who has history of hyperuricemia and gouty
arthritis experienced progressive shortness of breath for a week. Limited movement has been
complained by the patient because of her multiple painful swelling in her hands and elbows. She
has also mentioned new lesions in his ear lobes. The patient is a former smoker with 10 pack year
history and worked as a field laborer.
Doctor’s Diagnosis: Gouty arthritis
Nutrition:
Usual Dietary Intake:
24-hr recall:
Breakfast: Chickpea and legume salad, 1 cup non-fat milk
Snack: Bean sprouts, poached eggs, nut parfait
Lunch: Fried chicken sandwich from McDonald’s, French fries, 32-oz iced tea
Late afternoon: 2 c chips, 1 beer
Dinner: 1 breast, fried Fried Chicken, 1½ c potato salad, ¼ c green
bean casserole, ½ c fruit salad, 1 c baked beans, iced tea
4. One treatment for hyperuricemia is administration of xanthine oxidase inhibitors like
allopurinol. What is the biochemical rationale for this treatment? Discuss the
mechanism and show an illustration how this drug able to alleviate symptoms of
hyperuricemia?
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