An 8-year-old girl is brought to the physician with the concern of irregular low-grade fever and gradually increasing fatigue for the last 2 years. She has a history of hearing loss and has not been keeping well since birth. Physical examination shows short stature, frontal bossing, and hepatosplenomegaly. An X-ray shows multiple healed fractures, generalized increased bone density, and widening of the metaphyses of the ulna and radius. Laboratory studies reveal normocytic anemia and thrombocytopenia. Which of the following is the most likely underlying mechanism of these effects? Answers A - E A Decreased osteoblast activity B Impaired synthesis of collagen C Increased osteoclast activity D Inhibition of endochondral growth E Reduced resorption of the bone O O O O

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
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An 8-year-old girl is brought to the physician with the concern of irregular low-grade fever and gradually increasing fatigue for the last 2 years. She has
a history of hearing loss and has not been keeping well since birth. Physical examination shows short stature, frontal bossing, and hepatosplenomegaly.
An X-ray shows multiple healed fractures, generalized increased bone density, and widening of the metaphyses of the ulna and radius. Laboratory
studies reveal normocytic anemia and thrombocytopenia. Which of the following is the most likely underlying mechanism of these effects?
Answers A - E
A Decreased osteoblast activity
B Impaired synthesis of collagen
C Increased osteoclast activity
D Inhibition of endochondral growth
E
Reduced resorption of the bone
O
Transcribed Image Text:An 8-year-old girl is brought to the physician with the concern of irregular low-grade fever and gradually increasing fatigue for the last 2 years. She has a history of hearing loss and has not been keeping well since birth. Physical examination shows short stature, frontal bossing, and hepatosplenomegaly. An X-ray shows multiple healed fractures, generalized increased bone density, and widening of the metaphyses of the ulna and radius. Laboratory studies reveal normocytic anemia and thrombocytopenia. Which of the following is the most likely underlying mechanism of these effects? Answers A - E A Decreased osteoblast activity B Impaired synthesis of collagen C Increased osteoclast activity D Inhibition of endochondral growth E Reduced resorption of the bone O
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