b) The hydrolysis of ATP is directly coupled to H* transport and the stoichiometry of the transport reaction is such that 1 mol of ATP is hydrolyzed for every 1 mol of H* transported into the stomach. ATP is hydrolyzed by the ATPase on the inside of the cell. Under the conditions given in part (a) and assuming the steady-state concentrations of ATP, ADP and P₁ given below, is the transport of H* in to the stomach thermodynamically favorable at 37 °C? Show the calculation that supports your answer. Steady-state intracellular concentrations: ADP = 360 μM ATP = 4.2 mM Pi = 5.4 mM For ATP hydrolysis at 37 °C: ATP + H₂O → ADP + Pi + H+ AG" = -32.2 kJ/mol.

b) The hydrolysis of ATP is directly coupled to H* transport and the stoichiometry of the transport reaction is such that 1 mol of ATP is hydrolyzed for every 1 mol of H* transported into the stomach. ATP is hydrolyzed by the ATPase on the inside of the cell. Under the conditions given in part (a) and assuming the steady-state concentrations of ATP, ADP and P₁ given below, is the transport of H* in to the stomach thermodynamically favorable at 37 °C? Show the calculation that supports your answer. Steady-state intracellular concentrations: ADP = 360 μM ATP = 4.2 mM Pi = 5.4 mM For ATP hydrolysis at 37 °C: ATP + H₂O → ADP + Pi + H+ AG" = -32.2 kJ/mol.

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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